Upregulation of GRIM‑19 inhibits the growth and invasion of human breast cancer cells

Retraction in: /10.3892/mmr.2021.12225

  • Authors:
    • Wei Zhang
    • Ye Du
    • Tong Jiang
    • Wei Geng
    • Jiuli Yuan
    • Duo Zhang
  • View Affiliations

  • Published online on: May 7, 2015     https://doi.org/10.3892/mmr.2015.3757
  • Pages: 2919-2925
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Abstract

Gene associated with retinoid‑interferon (IFN)‑induced mortality 19 (GRIM‑19), a novel IFN‑β/retinoic acid‑inducible gene product, has been identified as a potential tumor suppressor, which is associated with the inhibition of tumor growth. GRIM‑19 has been demonstrated to be downregulated in the ovarian tissue of patients with breast cancer, however, its role in breast cancer remains to be fully elucidated. In the present study, a recombinant eukaryotic expression plasmid carrying GRIM‑19 was constructed and then transfected into the MCF7 human breast cancer cell line to examine its effects on breast cancer cell growth, migration and invasion using several in vitro approaches. The results demonstrated that upregulation GRIM‑19 in the MCF7 cells significantly inhibited cell proliferation, colony formation, migration and invasion, and induced cell apoptosis. Additionally, upregulation of GRIM‑19 also suppressed the secretion of urokinase‑type plasminogen activator (u‑PA), matrix metalloproteinase (MMP)‑2, MMP‑9 and vascular endothelial growth factor (VEGF). It was also demonstrated that the activation of signal transducer and activator of transcription 3 (STAT3) was downregulated by the expression of GRIM‑19. These results revealed that overexpression of the GRIM‑19 gene may be an effective approach to control the growth and invasion of human breast cancer cells.
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August-2015
Volume 12 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Zhang W, Du Y, Jiang T, Geng W, Yuan J and Zhang D: Upregulation of GRIM‑19 inhibits the growth and invasion of human breast cancer cells Retraction in /10.3892/mmr.2021.12225. Mol Med Rep 12: 2919-2925, 2015
APA
Zhang, W., Du, Y., Jiang, T., Geng, W., Yuan, J., & Zhang, D. (2015). Upregulation of GRIM‑19 inhibits the growth and invasion of human breast cancer cells Retraction in /10.3892/mmr.2021.12225. Molecular Medicine Reports, 12, 2919-2925. https://doi.org/10.3892/mmr.2015.3757
MLA
Zhang, W., Du, Y., Jiang, T., Geng, W., Yuan, J., Zhang, D."Upregulation of GRIM‑19 inhibits the growth and invasion of human breast cancer cells Retraction in /10.3892/mmr.2021.12225". Molecular Medicine Reports 12.2 (2015): 2919-2925.
Chicago
Zhang, W., Du, Y., Jiang, T., Geng, W., Yuan, J., Zhang, D."Upregulation of GRIM‑19 inhibits the growth and invasion of human breast cancer cells Retraction in /10.3892/mmr.2021.12225". Molecular Medicine Reports 12, no. 2 (2015): 2919-2925. https://doi.org/10.3892/mmr.2015.3757