Toll-like receptor 2 and -4 are involved in the pathogenesis of the Guillain-Barré syndrome

  • Authors:
    • Yamei Du
    • Guojun Zhang
    • Zaiqiang Zhang
    • Qian Wang
    • Ruimin Ma
    • Limin Zhang
    • Fei Fan
    • Youran Li
    • Meng Wang
    • Hong Lv
    • Xixiong Kang
  • View Affiliations

  • Published online on: May 5, 2015     https://doi.org/10.3892/mmr.2015.3730
  • Pages: 3207-3213
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Abstract

Guillain-Barré syndrome (GBS) is an autoimmune disorder of the peripheral nervous system characterized by weakness in the limbs. To date, numerous hypotheses have been suggested to explain the pathogenesis of GBS; however, the pathogenesis of GBS remains to be elucidated. The aim of the present study was to investigate the association between Toll‑like receptor (TLR) 2, TLR4 and GBS. Therefore, the mRNA of TLR2, TLR4, myeloid differentiation factor (MyD)88 and nuclear factor (NF)‑κB of peripheral blood mononuclear cells (PBMCs) in patients with GBS and healthy controls was assessed. To confirm the function of TLR2 and TLR4 in the pathogenesis of GBS, PBMCs derived from patients with GBS and healthy controls were cultured with various TLR agonists. The levels of tumor necrosis factor (TNF)‑α and interleukin (IL)‑1β were measured in the culture supernatant and fasting serum was obtained for the detection of anti‑ganglioside antibodies. The results revealed that the mRNA levels of TLR2, TLR4, MyD88 and NF‑κB were significantly increased in patients with GBS compared with those in healthy controls (P=0.003, 0.017, 0.032 and 0.015, respectively). PBMCs from patients with GBS secreted higher levels of TNF‑α and IL‑1β than those from control subjects. The positive rate of immunoglobulin (Ig)G and IgM anti‑ganglioside antibodies in patients with severe GBS was 42.86%, which was markedly higher than rates found in patients with mild GBS (9.09 and 18.18%, respectively). The results of the present study demonstrated that TLR2 and TLR4 are involved in the pathogenesis of GBS and that they and their associated signaling pathways may be targets for the treatment of GBS.
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August-2015
Volume 12 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Du Y, Zhang G, Zhang Z, Wang Q, Ma R, Zhang L, Fan F, Li Y, Wang M, Lv H, Lv H, et al: Toll-like receptor 2 and -4 are involved in the pathogenesis of the Guillain-Barré syndrome. Mol Med Rep 12: 3207-3213, 2015
APA
Du, Y., Zhang, G., Zhang, Z., Wang, Q., Ma, R., Zhang, L. ... Kang, X. (2015). Toll-like receptor 2 and -4 are involved in the pathogenesis of the Guillain-Barré syndrome. Molecular Medicine Reports, 12, 3207-3213. https://doi.org/10.3892/mmr.2015.3730
MLA
Du, Y., Zhang, G., Zhang, Z., Wang, Q., Ma, R., Zhang, L., Fan, F., Li, Y., Wang, M., Lv, H., Kang, X."Toll-like receptor 2 and -4 are involved in the pathogenesis of the Guillain-Barré syndrome". Molecular Medicine Reports 12.2 (2015): 3207-3213.
Chicago
Du, Y., Zhang, G., Zhang, Z., Wang, Q., Ma, R., Zhang, L., Fan, F., Li, Y., Wang, M., Lv, H., Kang, X."Toll-like receptor 2 and -4 are involved in the pathogenesis of the Guillain-Barré syndrome". Molecular Medicine Reports 12, no. 2 (2015): 3207-3213. https://doi.org/10.3892/mmr.2015.3730