Zingiber mioga (Thunb.) Roscoe attenuates allergic asthma induced by ovalbumin challenge

  • Authors:
    • Na‑Rae Shin
    • In‑Sik Shin
    • Chan‑Mi Jeon
    • Ju‑Mi Hong
    • Ok‑Kyoung Kwon
    • Hui‑Seong Kim
    • Sei‑Ryang Oh
    • Kyu‑Woung Hahn
    • Kyung‑Seop Ahn
  • View Affiliations

  • Published online on: June 11, 2015     https://doi.org/10.3892/mmr.2015.3914
  • Pages: 4538-4545
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Abstract

Zingiber mioga (Thunb.) Roscoe (ZM) is a traditional medicine, used to treat inflammatory diseases. The present study aimed to evaluate the inhibitory effects of ZM on the inflammatory response in lipopolysaccharide (LPS)‑stimulated RAW264.7 murine macrophage cells and in a mouse model of ovalbumin (OVA)‑induced allergic asthma. Mice received OVA sensitization on day 0 and 14, and were challenged with OVA between days 21 and 23. ZM was administered to the mice at a dose of 30 mg/kg, 1 h prior to OVA challenge. In LPS‑stimulated RAW264.7 cells, ZM significantly decreased nitric oxide (NO) and tumor necrosis factor (TNF)‑α production in a concentration‑dependent manner, and mRNA expression of inducible NO synthase (iNOS), TNF‑α and matrix metalloproteinase (MMP)‑9 was reduced. In addition, treatment with ZM decreased the inflammatory cell count in bronchoalveolar lavage fluid from the mice, and reduced the expression of interleukin (IL)‑4, IL‑5, IL‑13, eotaxin and immunoglobulin E. ZM also reduced airway hyperresponsiveness in OVA‑challenged mice, and attenuated the infiltration of inflammatory cells and mucus production in the airways, with a decrease in the expression of iNOS and MMP‑9 in lung tissue. In conclusion, the results of the present study indicate that ZM effectively inhibits inflammatory responses. Therefore, it may be that ZM has potential as a therapeutic agent for use in inflammatory diseases.
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September-2015
Volume 12 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Shin NR, Shin IS, Jeon CM, Hong JM, Kwon OK, Kim HS, Oh SR, Hahn KW and Ahn KS: Zingiber mioga (Thunb.) Roscoe attenuates allergic asthma induced by ovalbumin challenge. Mol Med Rep 12: 4538-4545, 2015
APA
Shin, N., Shin, I., Jeon, C., Hong, J., Kwon, O., Kim, H. ... Ahn, K. (2015). Zingiber mioga (Thunb.) Roscoe attenuates allergic asthma induced by ovalbumin challenge. Molecular Medicine Reports, 12, 4538-4545. https://doi.org/10.3892/mmr.2015.3914
MLA
Shin, N., Shin, I., Jeon, C., Hong, J., Kwon, O., Kim, H., Oh, S., Hahn, K., Ahn, K."Zingiber mioga (Thunb.) Roscoe attenuates allergic asthma induced by ovalbumin challenge". Molecular Medicine Reports 12.3 (2015): 4538-4545.
Chicago
Shin, N., Shin, I., Jeon, C., Hong, J., Kwon, O., Kim, H., Oh, S., Hahn, K., Ahn, K."Zingiber mioga (Thunb.) Roscoe attenuates allergic asthma induced by ovalbumin challenge". Molecular Medicine Reports 12, no. 3 (2015): 4538-4545. https://doi.org/10.3892/mmr.2015.3914