Catabolite control protein A has an important role in the metabolic regulation of Streptococcus suis type 2 according to iTRAQ-based quantitative proteomic analysis

  • Authors:
    • Xulong Lang
    • Zhonghai Wan
    • Ying Pan
    • Zhaoyang Bu
    • Xiuran Wang
    • Xiaoxu Wang
    • Xue Ji
    • Lingwei Zhu
    • Jiayu Wan
    • Yang Sun
    • Xinglong Wang
  • View Affiliations

  • Published online on: August 11, 2015     https://doi.org/10.3892/mmr.2015.4211
  • Pages: 5967-5972
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The catabolite control protein A (ccpA) regulates the carbon metabolism in Streptococcus suis type 2 and has pleiotropic regulatory functions in bacterial virulence and transcription. The present study systematically investigated ccpA activity in Streptococcus suis type 2 using isobaric tag for relative and absolute quantification (iTRAQ) liquid chromatography‑tandem mass spectrometry‑based proteomics. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses demonstrated that ccpA is an important protein for the regulation of metabolism, virulence and immune pathways in Streptococcus suis type 2. The present study therefore expanded the current understanding of the effects of ccpA on virulence, metabolic regulation and transcription in Streptococcus suis type 2 and other important pathogens.
View Figures
View References

Related Articles

Journal Cover

October-2015
Volume 12 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Lang X, Wan Z, Pan Y, Bu Z, Wang X, Wang X, Ji X, Zhu L, Wan J, Sun Y, Sun Y, et al: Catabolite control protein A has an important role in the metabolic regulation of Streptococcus suis type 2 according to iTRAQ-based quantitative proteomic analysis. Mol Med Rep 12: 5967-5972, 2015
APA
Lang, X., Wan, Z., Pan, Y., Bu, Z., Wang, X., Wang, X. ... Wang, X. (2015). Catabolite control protein A has an important role in the metabolic regulation of Streptococcus suis type 2 according to iTRAQ-based quantitative proteomic analysis. Molecular Medicine Reports, 12, 5967-5972. https://doi.org/10.3892/mmr.2015.4211
MLA
Lang, X., Wan, Z., Pan, Y., Bu, Z., Wang, X., Wang, X., Ji, X., Zhu, L., Wan, J., Sun, Y., Wang, X."Catabolite control protein A has an important role in the metabolic regulation of Streptococcus suis type 2 according to iTRAQ-based quantitative proteomic analysis". Molecular Medicine Reports 12.4 (2015): 5967-5972.
Chicago
Lang, X., Wan, Z., Pan, Y., Bu, Z., Wang, X., Wang, X., Ji, X., Zhu, L., Wan, J., Sun, Y., Wang, X."Catabolite control protein A has an important role in the metabolic regulation of Streptococcus suis type 2 according to iTRAQ-based quantitative proteomic analysis". Molecular Medicine Reports 12, no. 4 (2015): 5967-5972. https://doi.org/10.3892/mmr.2015.4211