Electroacupuncture ameliorates learning and memory in rats with cerebral ischemia-reperfusion injury by inhibiting oxidative stress and promoting p-CREB expression in the hippocampus

  • Authors:
    • Ruhui Lin
    • Yukun Lin
    • Jing Tao
    • Bin Chen
    • Kunqiang Yu
    • Jixiang Chen
    • Xiaojie Li
    • Li‑Dian Chen
  • View Affiliations

  • Published online on: September 14, 2015     https://doi.org/10.3892/mmr.2015.4321
  • Pages: 6807-6814
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Abstract

The present study aimed to investigate the mechanisms by which electroacupuncture (EA) ameliorates learning and memory in rats with cerebral ischemic‑reperfusion (I/R) injury. Focal cerebral ischemia was induced in adult male Sprague‑Dawley (SD) rats by transient middle cerebral artery occlusion (MCAO). Following MCAO surgery, the rats received EA at the Shenting (DU24) and Baihui (DU20) acupoints. The results of the present study demonstrated that treatment with EA significantly ameliorated neurological deficits and reduced cerebral infarct volume (P<0.05). In addition, EA improved the learning and memory ability of the rats, and markedly activated the cyclic adenosine monophosphate (cAMP) response element‑binding protein (CREB) signaling pathway, resulting in the inhibition of cerebral cell apoptosis in the ischemic penumbra. Furthermore, EA increased the activity of superoxide dismutase and glutathione peroxidase, the protein expression levels of phosphorylated‑CREB and B‑cell lymphoma 2 (Bcl‑2), and the mRNA expression levels of Bcl‑2. Conversely, EA decreased the levels of malondialdehyde and inhibited the expression levels of Bcl2‑associated X protein. The results of the present study suggest that treatment with EA may result in the amelioration of learning and memory ability in rats with cerebral I/R injury.
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November-2015
Volume 12 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Lin R, Lin Y, Tao J, Chen B, Yu K, Chen J, Li X and Chen LD: Electroacupuncture ameliorates learning and memory in rats with cerebral ischemia-reperfusion injury by inhibiting oxidative stress and promoting p-CREB expression in the hippocampus. Mol Med Rep 12: 6807-6814, 2015
APA
Lin, R., Lin, Y., Tao, J., Chen, B., Yu, K., Chen, J. ... Chen, L. (2015). Electroacupuncture ameliorates learning and memory in rats with cerebral ischemia-reperfusion injury by inhibiting oxidative stress and promoting p-CREB expression in the hippocampus. Molecular Medicine Reports, 12, 6807-6814. https://doi.org/10.3892/mmr.2015.4321
MLA
Lin, R., Lin, Y., Tao, J., Chen, B., Yu, K., Chen, J., Li, X., Chen, L."Electroacupuncture ameliorates learning and memory in rats with cerebral ischemia-reperfusion injury by inhibiting oxidative stress and promoting p-CREB expression in the hippocampus". Molecular Medicine Reports 12.5 (2015): 6807-6814.
Chicago
Lin, R., Lin, Y., Tao, J., Chen, B., Yu, K., Chen, J., Li, X., Chen, L."Electroacupuncture ameliorates learning and memory in rats with cerebral ischemia-reperfusion injury by inhibiting oxidative stress and promoting p-CREB expression in the hippocampus". Molecular Medicine Reports 12, no. 5 (2015): 6807-6814. https://doi.org/10.3892/mmr.2015.4321