Open Access

Ki-67 labeling index affects tumor infiltration patterns of lung squamous cell carcinoma

  • Authors:
    • Daisuke Masuda
    • Ryota Masuda
    • Tomohiko Matsuzaki
    • Naoko Imamura
    • Naohiro Aruga
    • Makiko Tanaka
    • Sadaki Inokuchi
    • Hiroshi Kijima
    • Masayuki Iwazaki
  • View Affiliations

  • Published online on: September 24, 2015     https://doi.org/10.3892/mmr.2015.4354
  • Pages: 7303-7309
  • Copyright: © Masuda et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ki-67 is a nuclear protein that is expressed during the G1, S, G2 and M phases of the mitotic cell cycle. A previous study categorized tumor infiltration patterns (INF), of which INFc indicated cancer nests exhibiting infiltrative growth and an unclear boundary between tumor tissue and surrounding healthy tissue. The present study used the Ki‑67 labeling index (Ki‑67 LI) as an indicator of cell proliferation, in order to examine the factors affecting INF in lung squamous cell carcinoma (SqCC). SqCC specimens (89) were classified into two groups: High‑grade cell proliferation (Ki‑67 LI ≥30%) and low‑grade cell proliferation (Ki‑67 LI <30%). However, a high Ki‑67 LI was significantly associated with cases that had an INFc component [INFc(+); P=0.03]. Univariate analyses indicated that INFc(+) was a predictor of venous invasion [P=0.032; odds ratio (OR), 2.615; 95% confidence interval (95% CI), 1.085‑6.305], scirrhous stromal type (P<0.001; OR, 6.462; 95% CI, 2.483‑16.817) and high Ki‑67 LI (P=0.018; OR, 12.543; 95% CI, 1.531‑102.777). Multivariate logistic analyses indicated that high Ki‑67 LI was the strongest predictor of INFc(+) (P=0.028; OR, 8.027; 95% CI, 1.248‑51.624). In conclusion, high‑grade cell proliferation activity may contribute to aggressive infiltrative growth of lung SqCC.
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November-2015
Volume 12 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Masuda D, Masuda R, Matsuzaki T, Imamura N, Aruga N, Tanaka M, Inokuchi S, Kijima H and Iwazaki M: Ki-67 labeling index affects tumor infiltration patterns of lung squamous cell carcinoma. Mol Med Rep 12: 7303-7309, 2015
APA
Masuda, D., Masuda, R., Matsuzaki, T., Imamura, N., Aruga, N., Tanaka, M. ... Iwazaki, M. (2015). Ki-67 labeling index affects tumor infiltration patterns of lung squamous cell carcinoma. Molecular Medicine Reports, 12, 7303-7309. https://doi.org/10.3892/mmr.2015.4354
MLA
Masuda, D., Masuda, R., Matsuzaki, T., Imamura, N., Aruga, N., Tanaka, M., Inokuchi, S., Kijima, H., Iwazaki, M."Ki-67 labeling index affects tumor infiltration patterns of lung squamous cell carcinoma". Molecular Medicine Reports 12.5 (2015): 7303-7309.
Chicago
Masuda, D., Masuda, R., Matsuzaki, T., Imamura, N., Aruga, N., Tanaka, M., Inokuchi, S., Kijima, H., Iwazaki, M."Ki-67 labeling index affects tumor infiltration patterns of lung squamous cell carcinoma". Molecular Medicine Reports 12, no. 5 (2015): 7303-7309. https://doi.org/10.3892/mmr.2015.4354