MG132 proteasome inhibitor upregulates the expression of connexin 43 in rats with adriamycin-induced heart failure

  • Authors:
    • Guiying Chen
    • Jiyi Zhao
    • Chunyan Liu
    • Yina Zhang
    • Yanping Huo
    • Lijun Zhou
  • View Affiliations

  • Published online on: September 21, 2015     https://doi.org/10.3892/mmr.2015.4337
  • Pages: 7595-7602
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Abstract

The connexin 43 (Cx43) gap junction protein is important in the synchronization of contraction of cardiac myocytes. Abnormal expression of Cx43 contributes to ventricular arrhythmia, which is the major cause of sudden death in heart failure (HF). Cx43 is known to interact with zonula occludens (ZO)‑1, and the proteasome is involved in the regulation of Cx43 degradation. Although Cx43 is downregulated in heart failure, the underlying mechanisms remain to be elucidated. The present study aimed to investigate the effect of the MG132 proteasome inhibitor on the expression levels of Cx43, ZO‑1, 20S proteasome and ubiquitin in a rat model of HF, induced by adriamycin. MG132 reduced adriamycin‑induced injury in the failing heart. In addition, MG132 inhibited the expression of 20S proteasome and ubiquitin, accompanied by an upregulation in the expression of Cx43 and ZO‑1. These findings suggested that inhibition of the ubiquitin‑proteasome system upregulated the expression of Cx43. Therefore, the proteasome inhibitor may be used to prevent degradation of Cx43 in HF, and thus may prevent Cx43-mediated arrhythmia in HF.
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November-2015
Volume 12 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Chen G, Zhao J, Liu C, Zhang Y, Huo Y and Zhou L: MG132 proteasome inhibitor upregulates the expression of connexin 43 in rats with adriamycin-induced heart failure. Mol Med Rep 12: 7595-7602, 2015
APA
Chen, G., Zhao, J., Liu, C., Zhang, Y., Huo, Y., & Zhou, L. (2015). MG132 proteasome inhibitor upregulates the expression of connexin 43 in rats with adriamycin-induced heart failure. Molecular Medicine Reports, 12, 7595-7602. https://doi.org/10.3892/mmr.2015.4337
MLA
Chen, G., Zhao, J., Liu, C., Zhang, Y., Huo, Y., Zhou, L."MG132 proteasome inhibitor upregulates the expression of connexin 43 in rats with adriamycin-induced heart failure". Molecular Medicine Reports 12.5 (2015): 7595-7602.
Chicago
Chen, G., Zhao, J., Liu, C., Zhang, Y., Huo, Y., Zhou, L."MG132 proteasome inhibitor upregulates the expression of connexin 43 in rats with adriamycin-induced heart failure". Molecular Medicine Reports 12, no. 5 (2015): 7595-7602. https://doi.org/10.3892/mmr.2015.4337