Open Access

NADPH oxidase 3‑associated oxidative stress and caspase 3‑dependent apoptosis in the cochleae of D‑galactose‑induced aged rats

Corrigendum in: /10.3892/mmr.2015.4590

  • Authors:
    • Zhengde Du
    • Shuo Li
    • Lin Liu
    • Qiong Yang
    • Hongwei Zhang
    • Chunsheng Gao
  • View Affiliations

  • Published online on: October 13, 2015     https://doi.org/10.3892/mmr.2015.4430
  • Pages: 7883-7890
  • Copyright: © Du et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Oxidative damage to mitochondrial DNA (mtDNA) and cell apoptosis are heavily implicated in aging. Our previous study established a mimetic rat model of aging in the cochleae using D‑galactose (D‑gal), and revealed that chronic injection of D‑gal can increase oxidative stress and mtDNA common deletions (CD). The aim of the present study was to investigate the sources of reactive oxygen species and the occurrence of apoptosis in the cochleae of rats following 8 weeks of D‑gal exposure. The results of the present study indicated that an elevated accumulation of the mtDNA CD and mitochondrial ultrastructural damage occurred in the cochleae of rats injected with D‑gal for 8 weeks. In addition, the levels of 8‑hydroxy‑2‑deoxyguanosine, NADPH oxidase (NOX) 3, P22phox and cleaved caspase 3, and the number of terminal deoxynucleotidyl transferase‑mediated deoxyuridine triphosphate nick‑end‑labelling‑positive cells were increased in the cochleae of D‑gal‑treated rats, compared with the controls. These findings suggested that nitric oxide synthase NOX3‑associated oxidative stress may contribute to the accumulation of mtDNA mutations and activate a caspase 3‑dependent apoptotic signalling pathway in the cochleae during aging. The present study also provided novel insights into the development of age‑associated hearing loss, also termed presbycusis.
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December-2015
Volume 12 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Du Z, Li S, Liu L, Yang Q, Zhang H and Gao C: NADPH oxidase 3‑associated oxidative stress and caspase 3‑dependent apoptosis in the cochleae of D‑galactose‑induced aged rats Corrigendum in /10.3892/mmr.2015.4590. Mol Med Rep 12: 7883-7890, 2015
APA
Du, Z., Li, S., Liu, L., Yang, Q., Zhang, H., & Gao, C. (2015). NADPH oxidase 3‑associated oxidative stress and caspase 3‑dependent apoptosis in the cochleae of D‑galactose‑induced aged rats Corrigendum in /10.3892/mmr.2015.4590. Molecular Medicine Reports, 12, 7883-7890. https://doi.org/10.3892/mmr.2015.4430
MLA
Du, Z., Li, S., Liu, L., Yang, Q., Zhang, H., Gao, C."NADPH oxidase 3‑associated oxidative stress and caspase 3‑dependent apoptosis in the cochleae of D‑galactose‑induced aged rats Corrigendum in /10.3892/mmr.2015.4590". Molecular Medicine Reports 12.6 (2015): 7883-7890.
Chicago
Du, Z., Li, S., Liu, L., Yang, Q., Zhang, H., Gao, C."NADPH oxidase 3‑associated oxidative stress and caspase 3‑dependent apoptosis in the cochleae of D‑galactose‑induced aged rats Corrigendum in /10.3892/mmr.2015.4590". Molecular Medicine Reports 12, no. 6 (2015): 7883-7890. https://doi.org/10.3892/mmr.2015.4430