Open Access

p53 causes butein‑mediated apoptosis of chronic myeloid leukemia cells

  • Authors:
    • Sang‑Mi Woo
    • Youn Kynug Choi
    • Ah Jeong Kim
    • Sung‑Gook Cho
    • Seong‑Gyu Ko
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  • Published online on: December 10, 2015     https://doi.org/10.3892/mmr.2015.4672
  • Pages: 1091-1096
  • Copyright: © Woo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Progression of chronic myeloid leukemia, marked by the oncogenic Bcr‑Abl mutation, is tightly associated with an alteration of the p53 pathway. It is known that butein extracted from various plants represses cancer growth. Although the anticancer effects of butein are widely accepted, the mechanisms by which butein induces apoptosis of chronic myeloid leukemia cells remains to be elucidated. The present study demonstrated that butein‑induced apoptosis was mediated by p53. KBM5 chronic myeloid leukemia (CML) cells expressing wild‑type p53 were more sensitive to butein compared with p53‑null K562 CML cells in terms of apoptotic cell death. In addition, butein arrested KBM5 cells at S‑phase and altered the expression levels of certain cyclins and the p53‑downstream targets, MDM2 and p21. In addition, while butein reduced the protein expression of MDM2 in the KBM5 and K562 cells, it resulted in proteasome‑independent MDM2 degradation in p53‑expressing KBM5 cells, however, not in p53‑null K562 cells. Therefore, the present study suggested that p53 causes the butein‑mediated apoptosis of leukemic cells.
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February-2016
Volume 13 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Woo SM, Choi YK, Kim AJ, Cho SG and Ko SG: p53 causes butein‑mediated apoptosis of chronic myeloid leukemia cells. Mol Med Rep 13: 1091-1096, 2016
APA
Woo, S., Choi, Y.K., Kim, A.J., Cho, S., & Ko, S. (2016). p53 causes butein‑mediated apoptosis of chronic myeloid leukemia cells. Molecular Medicine Reports, 13, 1091-1096. https://doi.org/10.3892/mmr.2015.4672
MLA
Woo, S., Choi, Y. K., Kim, A. J., Cho, S., Ko, S."p53 causes butein‑mediated apoptosis of chronic myeloid leukemia cells". Molecular Medicine Reports 13.2 (2016): 1091-1096.
Chicago
Woo, S., Choi, Y. K., Kim, A. J., Cho, S., Ko, S."p53 causes butein‑mediated apoptosis of chronic myeloid leukemia cells". Molecular Medicine Reports 13, no. 2 (2016): 1091-1096. https://doi.org/10.3892/mmr.2015.4672