Adenosine triphosphate-sensitive potassium channels and cardiomyopathies (Review)
- Authors:
- Zhongwei Liu
- Hui Cai
- Yonghui Dang
- Chuan Qiu
- Junkui Wang
-
Affiliations: Department of Cardiology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710068, P.R. China, Department of Anesthesiology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, College of Medicine and Forensics, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi 710061, P.R. China, Department of Biostatistics and Bioinformatics, School of Public Health and Tropical Medicine, Tulane University, New Orleans 70112‑2705, LA, USA - Published online on: December 23, 2015 https://doi.org/10.3892/mmr.2015.4714
- Pages: 1447-1454
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|
Rapposelli S: Novel adenosine 5′-triphosphate-sensitive potassium channel ligands: a patent overview (2005–2010). Expert Opin Ther Pat. 21:355–379. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Delaney JT, Muhammad R, Blair MA, Kor K, Fish FA, Roden DM and Darbar D: A KCNJ8 mutation associated with early repolarization and atrial fibrillation. Europace. 14:1428–1432. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Yamada S, Kane GC, Behfar A, Liu XK, Dyer RB, Faustino RS, Miki T, Seino S and Terzic A: Protection conferred by myocardial ATP-sensitive K+ channels in pressure overload-induced congestive heart failure revealed in KCNJ11 Kir6.2-null mutant. J Physiol. 577:1053–1065. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Fatima N, Schooley JF Jr, Claycomb WC and Flagg TP: Promoter DNA methylation regulates murine SUR1 (Abcc8) and SUR2 (Abcc9) expression in HL-1 cardiomyocytes. PLoS One. 7:e415332012. View Article : Google Scholar : PubMed/NCBI | |
|
Shi Y, Wu Z, Cui N, Shi W, Yang Y, Zhang X, Rojas A, Ha BT and Jiang C: PKA phosphorylation of SUR2B subunit underscores vascular KATP channel activation by beta-adrenergic receptors. Am J Physiol Regul Integr Comp Physiol ATP. 293:R1205–R1214. 2007. View Article : Google Scholar | |
|
Zhou M, He HJ, Suzuki R, Liu KX, Tanaka O, Sekiguchi M, Itoh H, Kawahara K and Abe H: Localization of sulfonylurea receptor subunits, SUR2A and SUR2B, in rat heart. J Histochem Cytochem. 55:795–804. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Shyng S and Nichols CG: Octameric stoichiometry of the KATP channel complex. J Gen Physiol. 110:655–664. 1997. View Article : Google Scholar | |
|
Nakaya H: Role of ATP-sensitive K+ channels in cardiac arrhythmias. J Cardiovasc Pharmacol Ther. 19:237–243. 2014. View Article : Google Scholar | |
|
Kang Y, Ng B, Leung YM, He Y, Xie H, Lodwick D, Norman RI, Tinker A, Tsushima RG and Gaisano HY: Syntaxin-1A actions on sulfonylurea receptor 2A can block acidic pH-induced cardiac K(ATP) channel activation. J Biol Chem. 281:19019–19028. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Damaj L, le Lorch M, Verkarre V, Werl C, Hubert L, Nihoul-Fékété C, Aigrain Y, de Keyzer Y, Romana SP, Bellanne-Chantelot C, et al: Chromosome 11p15 paternal isodisomy in focal forms of neonatal hyperinsulinism. J Clin Endocrinol Metab. 93:4941–4947. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Inagaki N, Gonoi T, Clement JP IV, Namba N, Inazawa J, Gonzalez G, Aguilar-Bryan L, Seino S and Bryan J: Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor. Science. 270:1166–1170. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Park S and Terzic A: Quaternary structure of KATP channel SUR2A nucleotide binding domains resolved by synchrotron radiation X-ray scattering. Struct Biol. 169:243–251. 2010. View Article : Google Scholar | |
|
Durell SR and Guy HR: A family of putative Kir potassium channels in prokaryotes. BMC Evol Biol. 1:142001. View Article : Google Scholar | |
|
Aggarwal NT, Shi NQ and Makielski JC: ATP-sensitive potassium currents from channels formed by Kir6 and a modified cardiac mitochondrial SUR2 variant. Channels (Austin). 7:493–502. 2013. View Article : Google Scholar | |
|
Chan KW, Zhang H and Logothetis DE: N-terminal trans-membrane domain of the SUR controls trafficking and gating of Kir6 channel subunits. EMBO J. 22:3833–3843. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Mori H and Ito K: The long alpha-helix of SecA is important for the ATPase coupling of translocation. J Biol Chem. 281:36249–36256. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Baczko I, Husti Z, Lang V, Leprán I and Light PE: Sarcolemmal KATP channel modulators and cardiac arrhythmias. Curr Med Chem. 18:3640–3661. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Nichols CG, Singh GK and Grange DK: KATP channels and cardiovascular disease: Suddenly a syndrome. Circ Res. 112:1059–1072. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Nichols CG: KATP channels as molecular sensors of cellular metabolism. Nature. 440:470–476. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Haissaguerre M, Chatel S, Sacher F, Weerasooriya R, Probst V, Loussouarn G, Horlitz M, Liersch R, Schulze-Bahr E, Wilde A, et al: Ventricular fibrillation with prominent early repolarization associated with a rare variant of KCNJ8/KATP channel. J Cardiovasc Electrophysiol. 20:93–98. 2009. View Article : Google Scholar | |
|
Fox JE, Magga J, Giles WR and Light PE: Acyl coenzyme A esters differentially activate cardiac and beta-cell adenosine triphosphate-sensitive potassium channels in a side-chain length-specific manner. Metabolism. 52:1313–1319. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
John SA, Weiss JN and Ribalet B: ATP sensitivity of ATP-sensitive K+ channels: Role of the gamma phosphate group of ATP and the R50 residue of mouse Kir6.2. J Physiol. 568:931–940. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Antcliff JF, Haider S, Proks P, Sansom MS and Ashcroft FM: Functional analysis of a structural model of the ATP-binding site of the KATP channel Kir6.2 subunit. EMBO J. 24:229–239. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Enkvetchakul D and Nichols CG: Gating mechanism of KATP channels: Function fits form. J Gen Physiol. 122:471–480. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Ribalet B, John SA and Weiss JN: Molecular basis for Kir6.2 channel inhibition by adenine nucleotides. Biophys J. 84:266–276. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Trapp S, Haider S, Jones P, Sansom MS and Ashcroft FM: Identification of residues contributing to the ATP binding site of Kir6.2. EMBO J. 22:2903–2912. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Enkvetchakul D, Jeliazkova I, Bhattacharyya J and Nichols CG: Control of inward rectifier K channel activity by lipid tethering of cytoplasmic domains. J Gen Physiol. 130:329–334. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Ribalet B, John SA, Xie LH and Weiss JN: ATP-sensitive K+ channels: Regulation of bursting by the sulphonylurea receptor, PIP2 and regions of Kir6.2. J Physiol. 571:303–317. 2006. View Article : Google Scholar | |
|
Pegan S, Arrabit C, Zhou W, Kwiatkowski W, Collins A, Slesinger PA and Choe S: Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification. Nat Neurosci. 8:279–287. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Hund TJ and Mohler PJ: Differential roles for SUR subunits in KATP channel membrane targeting and regulation. Am J Physiol Heart Circ Physiol. 300:H33–H35. 2011. View Article : Google Scholar | |
|
Cui N, Kang Y, He Y, Leung YM, Xie H, Pasyk EA, Gao X, Sheu L, Hansen JB, Wahl P, et al: H3 domain of syntaxin 1A inhibits KATP channels by its actions on the sulfonylurea receptor 1 nucleotide-binding folds-1 and -2. J Biol Chem. 279:53259–53265. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Ueda K, Inagaki N and Seino S: MgADP antagonism to Mg2+-independent ATP binding of the sulfonylurea receptor SUR1. J Biol Chem. 272:22983–22986. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Babenko AP and Bryan J: Sur domains that associate with and gate KATP pores define a novel gatekeeper. J Biol Chem. 278:41577–41580. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Tsounapi P, Satio M, Dimitriadis F, Kitatani K, Kinoshita Y, Shomori K, Takenaka A and Satoh K: The role of K ATP channels on ischemia-reperfusion injury in the rat testis. Life Sci. 90:649–656. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Glukhov AV, Flagg TP, Fedorov VV, Efimov IR and Nichols CG: Differential K (ATP) channel pharmacology in intact mouse heart. J Mol Cell Cardiol. 48:152–160. 2010. View Article : Google Scholar | |
|
Glukhov AV, Uchida K, Efimov IR and Nichols CG: Functional roles of KATP channel subunits in metabolic inhibition. J Mol Cell Cardiol. 62:90–98. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Marinovic J, Ljubkovic M, Stadnicka A, Bosnjak ZJ and Bienengraeber M: Role of sarcolemmal ATP-sensitive potassium channel in oxidative stress-induced apoptosis: Mitochondrial connection. Am J Physiol Heart Circ Physiol. 294:H1317–H1325. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang DM, Chai Y, Erickson JR, Brown JH, Bers DM and Lin YF: Intracellular signalling mechanism responsible for modulation of sarcolemmal ATP-sensitive potassium channels by nitric oxide in ventricular cardiomyocytes. J Physiol. 592:971–990. 2014. View Article : Google Scholar : | |
|
Voitychuk OI, Strutynskyi RB, Yagupolskii LM, Tinker A, Moibenko OO and Shuba YM: Sarcolemmal cardiac K(ATP) channels as a target for the cardioprotective effects of the fluorine-containing pinacidil analogue, flocalin. Br J Pharmacol. 162:701–711. 2011. View Article : Google Scholar : | |
|
Xie C, Hu J, Motloch LJ, Karam BS and Akar FG: The classically cardioprotective agent diazoxide elicits arrhythmias in type 2 diabetes mellitus. J Am Coll Cardiol. 66:1144–1156. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Y, Ren G, O'Rourke B, Marban E and Seharaseyon J: Pharmacological comparison of native mitochondrial K (ATP) channels with molecularly defined surface K (ATP) channels. Mol Pharmacol. 59:225–230. 2001.PubMed/NCBI | |
|
Suzuki M, Sasaki N, Miki T, Sakamoto N, Ohmoto-Sekine Y, Tamagawa M, Seino S, Marbán E and Nakaya H: Role of sarcolemmal K(ATP) channels in cardioprotection against ischemia/reperfusion injury in mice. J Clin Invest. 109:509–516. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Foster DB, Rucker JJ and Marban E: Is Kir6.1 a subunit of mitoK(ATP)? Biochem Biophys Res Commun. 366:649–656. 2008. View Article : Google Scholar : | |
|
Pu JL, Ye B, Kroboth SL, McNally EM, Makielski JC and Shi NQ: Cardiac sulfonylurea receptor short form-based channels confer a glibenclamide-insensitive KATP activity. J Mol Cell Cardiol. 44:188–200. 2008. View Article : Google Scholar | |
|
Mykytenko J, Reeves JG, Kin H, Wang NP, Zatta AJ, Jiang R, Guyton RA, Vinten-Johansen J and Zhao ZQ: Persistent beneficial effect of postconditioning against infarct size: Role of mitochondrial K(ATP) channels during reperfusion. Basic Res Cardiol. 103:472–484. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Hensley N, Dietrich J, Nyhan D, Mitter N, Yee MS and Brady M: Hypertrophic cardiomyopathy: a review. Anesth Analg. 120:554–569. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Teekakirikul P, Padera RF, Seidman JG and Seidman CE: Hypertrophic cardiomyopathy: Translating cellular cross talk into therapeutics. J Cell Biol. 199:417–421. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Vakrou S and Abraham MR: Hypertrophic cardiomyopathy: a heart in need of an energy bar? Front Physiol. 19:3092014. | |
|
Sodder VH, Bowie LD and Cameron JS: Trypsin alters ATP sensitivity of KATP channels in control and hypertrophied myocytes. Eur J Pharmacol. 315:115–118. 1996. View Article : Google Scholar : PubMed/NCBI | |
|
Rajesh KG, Sasaguri S, Suzuki R, Xing Y and Maeda H: Ischemic preconditioning prevents reperfusion heart injury in cardiac hypertrophy by activation of mitochondrial KATP channels. Int J Cardiol. 96:41–49. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Xia Y, Rajapurohitam V, Cook MA and Karmazyn M: Inhibition of phenylephrine induced hypertrophy in rat neonatal cardio-myocytes by the mitochondrial KATP channel opener diazoxide. J Mol Cell Cardiol. 37:1063–1067. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Yuan F, Brandt NR, Pinto JM, Wasserlauf BJ, Myerburg RJ and Bassett AL: Hypertrophy decreases cardiac KATP channel responsiveness to exogenous and locally generated (glycolytic) ATP. J Mol Cell Cardiol. 29:2837–2848. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Stoller D, Kakkar R, Smelley M, Chalupsky K, Earley JU, Shi NQ, Makielski JC and McNally EM: Mice lacking sulfonylurea receptor 2 (SUR2) ATP-sensitive potassium channels are resistant to acute cardiovascular stress. J Mol Cell Cardiol. 43:445–454. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Shimokawa J, Yokoshiki H and Tsutsui H: Impaired activation of ATP-sensitive K+ channels in endocardial myocytes from left ventricular hypertrophy. Am J Physiol Heart Circ Physiol. 293:H3643–H3649. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Gao S, Long CL, Wang RH and Wang H: K (ATP) activation prevents progression of cardiac hypertrophy to failure induced by pressure overload via protecting endothelial function. Cardiovasc Res. 83:444–456. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Hu X, Xu X, Huang Y, Fassett J, Flagg TP, Zhang Y, Nichols CG, Bache RJ and Chen Y: Disruption of sarcolemmal ATP-sensitive potassium channel activity impairs the cardiac response to systolic overload. Circ Res. 103:1009–1017. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Sanbe A: Dilated cardiomyopathy: A disease of the myocardium. Biol Pharm Bull. 36:18–22. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Luk A, Ahn E, Soor GS, Soor GS and Butany J: Dilated cardiomyopathy: a review. J Clin Pathol. 62:219–225. 2009. View Article : Google Scholar | |
|
Bienengraeber M, Olson TM, Selivanov VA, Kathmann EC, O'Cochlain F, Gao F, Karger AB, Ballew JD, Hodgson DM, Zingman LV, et al: ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating. Nat Genet. 36:382–387. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Farid TA, Nair K, Massé S, Azam MA, Maguy A, Lai PF, Umapathy K, Dorian P, Chauhan V, Varró A, et al: Role of KATP channels in the maintenance of ventricular fibrillation in cardiomyopathic human hearts. Circ Res. 109:1309–1318. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Grover GJ and Garlid KD: ATP-Sensitive potassium channels: A review of their cardioprotective pharmacology. J Mol Cell Cardiol. 32:677–695. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Yamada S, Nelson TJ, Crespo-Diaz RJ, Perez-Terzic C, Liu XK, Miki T, Seino S, Behfar A and Terzic A: Embryonic stem cell therapy of heart failure in genetic cardiomyopathy. Stem Cells. 26:2644–2653. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Cheung CY, Tso AW, Cheung BM, Xu A, Fong CH, Ong KL, Law LS, Wat NM, Janus ED, Sham PC, et al: The KCNJ11 E23 K polymorphism and progression of glycaemia in Southern Chinese: A long-term prospective study. PLoS One. 6:e285982011. View Article : Google Scholar | |
|
Xi HL, Liu JF, Li L and Wan J: Relationship between dilated cardiomyopathy and the E23K and I337V polymorphisms in the Kir6.2 subunit of the KATP channel. Genet Mol Res. 12:4383–4392. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Kalogeropoulos A, Georgiopoulou V, Kritchevsky SB, Psaty BM, Smith NL, Newman AB, Rodondi N, Satterfield S, Bauer DC, Bibbins-Domingo K, et al: Epidemiology of incident heart failure in a contemporary elderly cohort: The health, aging and body composition study. Arch Intern Med. 169:708–715. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Elrod JW and Molkentin JD: Physiologic functions of cyclophilin D and the mitochondrial permeability transition pore. Circ J. 77:1111–1122. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Rousou AJ, Ericsson M, Federman M, Levitsky S and McCully JD: Opening of mitochondrial KATP channels enhances cardioprotection through the modulation of mitochondrial matrix volume, calcium accumulation and respiration. Am J Physiol Heart Circ Physiol. 287:H1967–H1976. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
McPherson R and Davies RW: Inflammation and coronary artery disease: Insights from genetic studies. Can J Cardiol. 28:662–666. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Safranow K, Dziedziejko V, Rzeuski R, Czyzycka E, Wojtarowicz A, Bińczak-Kuleta A, Jakubowska K, Olszewska M, Ciechanowicz A, Kornacewicz-Jach Z, et al: Plasma concentrations of TNF-alpha and its soluble receptors sTNFR1 and sTNFR2 in patients with coronary artery disease. Tissue Antigens. 74:386–392. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou F, Yao HH, Wu JY, Ding JH, Sun T and Hu G: Opening of microglial K(ATP) channels inhibits rotenone-induced neuroinflammation. J Cell Mol Med. 12:1559–1570. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Kaspar RW, Allen HD and Montanaro F: Current understanding and management of dilated cardiomyopathy in Duchenne and Becker muscular dystrophy. J Am Acad Nurse Pract. 21:241–249. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Townsend D, Yasuda S and Metzger J: Cardiomyopathy of Duchenne muscular dystrophy: Pathogenesis and prospect of membrane sealants as a new therapeutic approach. Expert Rev Cardiovasc Ther. 5:99–109. 2007. View Article : Google Scholar | |
|
Graciotti L, Becker J, Granata AL, Procopio AD, Tessarollo L and Fulgenzi G: Dystrophin is required for the normal function of the cardio-protective K(ATP) channel in cardiomyocytes. PLoS One. 6:e270342011. View Article : Google Scholar : PubMed/NCBI | |
|
Pappachan JM, Varughese GI, Sriraman R and Arunagirinathan G: Diabetic cardiomyopathy: Pathophysiology, diagnostic evaluation and management. World J Diabetes. 4:177–189. 2013.PubMed/NCBI | |
|
Gloyn AL, Weedon MN, Owen KR, Turner MJ, Knight BA, Hitman G, Walker M, Levy JC, Sampson M, Halford S, et al: Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes. Diabetes. 52:568–572. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Mannikko R, Flanagan SE, Sim X, Segal D, Hussain K, Ellard S, Hattersley AT and Ashcroft FM: Mutations of the same conserved glutamate residue in NBD2 of the sulfonylurea receptor 1 subunit of the KATP channel can result in either hyperinsulinism or neonatal diabetes. Diabetes. 60:1813–1822. 2011. View Article : Google Scholar | |
|
Fancher IS, Dick GM and Hollander JM: Diabetes mellitus reduces the function and expression of ATP-dependent K(+) channels in cardiac mitochondria. Life Sci. 92:664–668. 2013. View Article : Google Scholar : | |
|
Chen ZC, Cheng YZ, Chen LJ, Cheng KC, Li Y and Cheng J: Increase of ATP-sensitive potassium (K(ATP)) channels in the heart of type-1 diabetic rats. Cardiovasc Diabetol. 11:82012. View Article : Google Scholar : PubMed/NCBI | |
|
Li GS, Wang F, Kang D and Li C: Keshan disease: An endemic cardiomyopathy in China. Hum Pathol. 16:602–609. 1985. View Article : Google Scholar : PubMed/NCBI | |
|
Lei C, Niu X, Ma X and Wei J: Is selenium deficiency really the cause of Keshan disease? Environ Geochem Health. 33:183–188. 2011. View Article : Google Scholar | |
|
Chen J: An original discovery: Selenium deficiency and Keshan disease (an endemic heart disease). Asia Pac J Clin Nutr. 21:320–326. 2012.PubMed/NCBI | |
|
Liu ZW, Niu XL, Chen KL, Xing YJ, Wang X, Qiu C and Gao DF: Selenium attenuates adriamycin-induced cardiac dysfunction via restoring expression of ATP-sensitive potassium channels in rats. Biol Trace Elem Res. 153:220–228. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Pereira SP, Pereira GC, Pereira CV, Carvalho FS, Cordeiro MH, Mota PC, Ramalho-Santos J, Moreno AJ and Oliveira PJ: Dioxin-induced acute cardiac mitochondrial oxidative damage and increased activity of ATP-sensitive potassium channels in Wistar rats. Environ Pollut. 180:281–290. 2013. View Article : Google Scholar : PubMed/NCBI |
