Open Access

Angiogenic factors in placentas from pregnancies complicated by fetal growth restriction (Review)

  • Authors:
    • Victor Gourvas
    • Efterpi Dalpa
    • Anastasia Konstantinidou
    • Nikolaos Vrachnis
    • Demetrios A. Spandidos
    • Stavros Sifakis
  • View Affiliations

  • Published online on: May 2, 2012     https://doi.org/10.3892/mmr.2012.898
  • Pages: 23-27
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The placenta is the organ that is responsible for providing the developing fetus with all the nutrients necessary for its growth and is also responsible for removing fetal waste. Placentation is a crucial process that includes angiogenesis. Angiogenesis involves not only the fetal circulation, but also placental and endometrial vascular changes. In this study, we review the literature regarding any impairment in the angiogenic process in placentas from pregnancies complicated by fetal growth restriction (FGR). Angiogenesis is regulated by a list of factors, also known as growth factors, such as the vascular endothelial growth factor (VEGF), the placental growth factor (PlGF) and the basic fibroblastic growth factor (bFGF), as well as the partial pressure of oxygen in the fetoplacental vessels. Other factors, such as transcriptional factors, also play a pivotal role, controlling the above-mentioned growth factors. Alterations in these pathways have been described in cases of growth-restricted fetuses. In this review, we provide an insight into these processes and identify the most crucial factors involved.

Related Articles

Journal Cover

July 2012
Volume 6 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Gourvas V, Dalpa E, Konstantinidou A, Vrachnis N, Spandidos DA and Sifakis S: Angiogenic factors in placentas from pregnancies complicated by fetal growth restriction (Review). Mol Med Rep 6: 23-27, 2012
APA
Gourvas, V., Dalpa, E., Konstantinidou, A., Vrachnis, N., Spandidos, D.A., & Sifakis, S. (2012). Angiogenic factors in placentas from pregnancies complicated by fetal growth restriction (Review). Molecular Medicine Reports, 6, 23-27. https://doi.org/10.3892/mmr.2012.898
MLA
Gourvas, V., Dalpa, E., Konstantinidou, A., Vrachnis, N., Spandidos, D. A., Sifakis, S."Angiogenic factors in placentas from pregnancies complicated by fetal growth restriction (Review)". Molecular Medicine Reports 6.1 (2012): 23-27.
Chicago
Gourvas, V., Dalpa, E., Konstantinidou, A., Vrachnis, N., Spandidos, D. A., Sifakis, S."Angiogenic factors in placentas from pregnancies complicated by fetal growth restriction (Review)". Molecular Medicine Reports 6, no. 1 (2012): 23-27. https://doi.org/10.3892/mmr.2012.898