Icaritin reverses multidrug resistance of HepG2/ADR human hepatoma cells via downregulation of MDR1 and P‑glycoprotein expression

  • Authors:
    • Li Sun
    • Weigang Chen
    • Lili Qu
    • Jie Wu
    • Jin Si
  • View Affiliations

  • Published online on: October 18, 2013     https://doi.org/10.3892/mmr.2013.1742
  • Pages: 1883-1887
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Multidrug resistance (MDR) of tumor cells is a serious obstacle encountered in cancer treatment. In the current study a multiple drug‑resistant HepG2/adriamycin (HepG2/ADR) cell line was established and its MDR was characterized. Icaritin, an active ingredient isolated from the medical plant Herba Epimedium, was observed to reverse MDR in the present model. Icaritin significantly increased the intracellular accumulation of ADR and decreased the expression of the MDR1 gene in HepG2/ADR cells compared with drug‑sensitive HepG2 cells. In addition, the present results showed that icaritin may significantly downregulate the expression of P‑glycoprotein. These results indicate that icaritin is a novel and potent MDR reversal agent and may be a promising drug for tumor chemotherapy.
View Figures
View References

Related Articles

Journal Cover

December 2013
Volume 8 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Sun L, Chen W, Qu L, Wu J and Si J: Icaritin reverses multidrug resistance of HepG2/ADR human hepatoma cells via downregulation of MDR1 and P‑glycoprotein expression. Mol Med Rep 8: 1883-1887, 2013
APA
Sun, L., Chen, W., Qu, L., Wu, J., & Si, J. (2013). Icaritin reverses multidrug resistance of HepG2/ADR human hepatoma cells via downregulation of MDR1 and P‑glycoprotein expression. Molecular Medicine Reports, 8, 1883-1887. https://doi.org/10.3892/mmr.2013.1742
MLA
Sun, L., Chen, W., Qu, L., Wu, J., Si, J."Icaritin reverses multidrug resistance of HepG2/ADR human hepatoma cells via downregulation of MDR1 and P‑glycoprotein expression". Molecular Medicine Reports 8.6 (2013): 1883-1887.
Chicago
Sun, L., Chen, W., Qu, L., Wu, J., Si, J."Icaritin reverses multidrug resistance of HepG2/ADR human hepatoma cells via downregulation of MDR1 and P‑glycoprotein expression". Molecular Medicine Reports 8, no. 6 (2013): 1883-1887. https://doi.org/10.3892/mmr.2013.1742