Irinotecan-based combination chemotherapy for metastatic small intestinal adenocarcinoma

  • Authors:
    • Yoshihiro Shibata
    • Eishi Baba
    • Hiroshi Ariyama
    • Shuji Arita
    • Taichi Isobe
    • Hitoshi Kusaba
    • Kenji Mitsugi
    • Shuji Nakano
    • Koichi Akashi
  • View Affiliations

  • Published online on: May 1, 2010     https://doi.org/10.3892/ol_00000074
  • Pages: 423-426
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Abstract

Metastatic small intestinal adenocarcinoma (SIA) is rare among digestive tract malignancies, and a standard therapy has yet to be established. The present study described a patient who was treated with irinotecan-based chemotherapy. A 67-year-old woman with a long history of anemia was diagnosed as having SIA using small bowel endoscopy. Tumor invasion of the mesentery and multiple metastases to the lungs and peritoneal lymph nodes were detected. Nine courses of chemotherapy, each consisting of bolus infusion of 5-fluorouracil at 500 mg/m2, plus infusion of irinotecan at 100 mg/m2 with l-leucovorin at 20 mg/m2 on days 1, 8 and 15, were administered at 4-weekly intervals postoperatively. After two courses, the metastatic nodules in the lungs showed a decrease in number and size, and this response continued for over 6 months. Adverse events were manageable during this period. The patient succumbed to the disease 12 months after the initial diagnosis. The present results therefore suggest that irinotecan-based chemotherapy is a potential treatment for metastatic SIA.
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May-June 2010
Volume 1 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Shibata Y, Baba E, Ariyama H, Arita S, Isobe T, Kusaba H, Mitsugi K, Nakano S and Akashi K: Irinotecan-based combination chemotherapy for metastatic small intestinal adenocarcinoma . Oncol Lett 1: 423-426, 2010
APA
Shibata, Y., Baba, E., Ariyama, H., Arita, S., Isobe, T., Kusaba, H. ... Akashi, K. (2010). Irinotecan-based combination chemotherapy for metastatic small intestinal adenocarcinoma . Oncology Letters, 1, 423-426. https://doi.org/10.3892/ol_00000074
MLA
Shibata, Y., Baba, E., Ariyama, H., Arita, S., Isobe, T., Kusaba, H., Mitsugi, K., Nakano, S., Akashi, K."Irinotecan-based combination chemotherapy for metastatic small intestinal adenocarcinoma ". Oncology Letters 1.3 (2010): 423-426.
Chicago
Shibata, Y., Baba, E., Ariyama, H., Arita, S., Isobe, T., Kusaba, H., Mitsugi, K., Nakano, S., Akashi, K."Irinotecan-based combination chemotherapy for metastatic small intestinal adenocarcinoma ". Oncology Letters 1, no. 3 (2010): 423-426. https://doi.org/10.3892/ol_00000074