Clinico-epidemiology of neuroblastoma in north east Egypt: A 5-year multicenter study

  • Authors:
    • Youssef Al‑Tonbary
    • Mohamed Badr
    • Ahmed Mansour
    • Usama El Safy
    • Shebl Saeed
    • Tamer Hassan
    • Rasha Elashery
    • Rofida Nofal
    • Ahmad Darwish
  • View Affiliations

  • Published online on: June 8, 2015     https://doi.org/10.3892/ol.2015.3335
  • Pages: 1054-1062
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Abstract

Neuroblastoma, an embryonal malignancy of the sympathetic nervous system, is the most frequent extracranial solid tumor The clinico‑epidemiological features of neuroblastoma in infants and children were investigated between January 2005 and January 2010 at the Pediatric Oncology units of Mansoura, Zagazig, and Tanta University Children's Hospitals (Egypt). Of 142 cases of neuroblastoma, 10 were omitted from the study due to defective data. The median age of the patients was 30 months, with 75.8% aged ≥1 year and 24.2% aged <1 year at time of diagnosis. The male‑to‑female ratio was 1.06. Suprarenal glands were the most common primary tumor site (72.7%). The majority of the patients (76.7%) had stage IV disease. Favorable pathology was observed in 43.8% of patients, while 56.2% exhibited unfavorable pathology. The estimated survival rate of patients was 30.7±10.0%, and mean survival time was 24.2±5.2 months. The rate of mortality was 28.6% for patients aged <1 year, and 81.8% for those aged ≥1 year (P=0.005). For patients with favorable pathology, the rate of mortality was significantly lower (28.6%) compared with that of patients with unfavorable pathology (77.8%; P=0.049). Although the association between outcome and each of the primary tumor sites, children's oncology group risk and gender was statistically insignificant, a large effect size was identified between outcome and primary tumor site, as well as children's oncology group risk and a medium effect size was identified between outcome and gender. Additionally, an age of ≥1 year was associated with unfavorable pathology (P=0.024), stage IV disease (P=0.026) and a suprarenal primary tumor site (P=0.001).
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August-2015
Volume 10 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Al‑Tonbary Y, Badr M, Mansour A, El Safy U, Saeed S, Hassan T, Elashery R, Nofal R and Darwish A: Clinico-epidemiology of neuroblastoma in north east Egypt: A 5-year multicenter study. Oncol Lett 10: 1054-1062, 2015
APA
Al‑Tonbary, Y., Badr, M., Mansour, A., El Safy, U., Saeed, S., Hassan, T. ... Darwish, A. (2015). Clinico-epidemiology of neuroblastoma in north east Egypt: A 5-year multicenter study. Oncology Letters, 10, 1054-1062. https://doi.org/10.3892/ol.2015.3335
MLA
Al‑Tonbary, Y., Badr, M., Mansour, A., El Safy, U., Saeed, S., Hassan, T., Elashery, R., Nofal, R., Darwish, A."Clinico-epidemiology of neuroblastoma in north east Egypt: A 5-year multicenter study". Oncology Letters 10.2 (2015): 1054-1062.
Chicago
Al‑Tonbary, Y., Badr, M., Mansour, A., El Safy, U., Saeed, S., Hassan, T., Elashery, R., Nofal, R., Darwish, A."Clinico-epidemiology of neuroblastoma in north east Egypt: A 5-year multicenter study". Oncology Letters 10, no. 2 (2015): 1054-1062. https://doi.org/10.3892/ol.2015.3335