Open Access

Clinical implications of PTEN and VEGF expression status, as well as microvessel density in esophageal squamous cell carcinoma

  • Authors:
    • Wei Qu
    • Jin‑Dong Fu
    • Fang Yang
    • Gong‑Li Yang
    • Ya‑Li Zhang
    • Xin‑Ying Wang
    • Hong‑Xiang Gu
    • Hai‑Yan Zhang
    • Ling Wang
  • View Affiliations

  • Published online on: June 29, 2015     https://doi.org/10.3892/ol.2015.3431
  • Pages: 1409-1415
  • Copyright: © Qu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

There are limitations to the use of single biomarker levels, for example phosphate and tensin homology (PTEN) or vascular endothelial growth factor (VEGF), in the diagnosis of esophageal squamous cell carcinoma (ESCC). The present study therefore aimed to evaluate the clinical implications of combined detection of multiple biomarkers. The associations between PTEN and VEGF expression status, microvessel density (MVD), and the pathological characteristics of 50 patients with ESCC were determined using χ2, analysis of variance, and t‑tests. The results indicated that the PTEN‑positive rate was negatively correlated with ESCC histological grade (P<0.01), depth of ESCC invasion (P<0.01) and lymph node metastasis status. Furthermore, the VEGF‑positive rate was correlated with lymph node metastasis status, while MVD was correlated with the depth of ESCC invasion (P<0.01) and lymph node metastasis status (P<0.05). The PTEN‑positive rate was negatively correlated with the VEGF‑positive rate. A higher MVD was identified in ESCC samples than that of the normal esophageal mucosa, particularly in VEGF‑positive ESCC specimens compared with those of VEGF‑negative specimens, and PTEN‑negative ESCC specimens compared with that of the PTEN‑positive ESCC specimens. These results suggested that combined detection of PTEN and VEGF levels, as well as evaluation of MVD in patients with ESCC may provide essential information for improvements in the diagnosis and prognosis of ESCC.
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September-2015
Volume 10 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Qu W, Fu JD, Yang F, Yang GL, Zhang YL, Wang XY, Gu HX, Zhang HY and Wang L: Clinical implications of PTEN and VEGF expression status, as well as microvessel density in esophageal squamous cell carcinoma. Oncol Lett 10: 1409-1415, 2015
APA
Qu, W., Fu, J., Yang, F., Yang, G., Zhang, Y., Wang, X. ... Wang, L. (2015). Clinical implications of PTEN and VEGF expression status, as well as microvessel density in esophageal squamous cell carcinoma. Oncology Letters, 10, 1409-1415. https://doi.org/10.3892/ol.2015.3431
MLA
Qu, W., Fu, J., Yang, F., Yang, G., Zhang, Y., Wang, X., Gu, H., Zhang, H., Wang, L."Clinical implications of PTEN and VEGF expression status, as well as microvessel density in esophageal squamous cell carcinoma". Oncology Letters 10.3 (2015): 1409-1415.
Chicago
Qu, W., Fu, J., Yang, F., Yang, G., Zhang, Y., Wang, X., Gu, H., Zhang, H., Wang, L."Clinical implications of PTEN and VEGF expression status, as well as microvessel density in esophageal squamous cell carcinoma". Oncology Letters 10, no. 3 (2015): 1409-1415. https://doi.org/10.3892/ol.2015.3431