Chronic neutrophilic leukemia with overexpression of EVI-1, and concurrent CSF3R and SETBP1 mutations: A case report

  • Authors:
    • Otgonbat Altangerel
    • Shannan Cao
    • Juanxia Meng
    • Peng Liu
    • Gong Haiyan
    • Yuanfu Xu
    • Mingfeng Zhao
  • View Affiliations

  • Published online on: July 13, 2015     https://doi.org/10.3892/ol.2015.3485
  • Pages: 1694-1700
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Abstract

Chronic neutrophilic leukemia (CNL) is a rare type of myeloproliferative neoplasm, characterized by sustained neutrophilia, splenomegaly, bone marrow granulocytic hyperplasia (without evidence of dysplasia) and an absence of the Philadelphia chromosome. Thus far, ~150 cases of CNL have been described in the literature; however, none have demonstrated overexpression of the ecotropic viral integration site‑1 (EVI‑1, also known as MECOM) gene. The present study describes a case that fulfilled the World Health Organization diagnostic criteria for CNL, and was associated with overexpression of EVI‑1, as well as novel concurrent mutations of colony stimulating factor 3 receptor (CSF3R) and SET binding protein‑1 (SETBP1). In addition, the current study briefly reviewed the relevant literature regarding novel genetic findings associated with the diagnosis and treatment of CNL. To the best of our knowledge, this is the first case report of CNL with associated EVI‑1 overexpression, and concurrent CSF3R and SETBP1 mutations.
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September-2015
Volume 10 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Altangerel O, Cao S, Meng J, Liu P, Haiyan G, Xu Y and Zhao M: Chronic neutrophilic leukemia with overexpression of EVI-1, and concurrent CSF3R and SETBP1 mutations: A case report. Oncol Lett 10: 1694-1700, 2015
APA
Altangerel, O., Cao, S., Meng, J., Liu, P., Haiyan, G., Xu, Y., & Zhao, M. (2015). Chronic neutrophilic leukemia with overexpression of EVI-1, and concurrent CSF3R and SETBP1 mutations: A case report. Oncology Letters, 10, 1694-1700. https://doi.org/10.3892/ol.2015.3485
MLA
Altangerel, O., Cao, S., Meng, J., Liu, P., Haiyan, G., Xu, Y., Zhao, M."Chronic neutrophilic leukemia with overexpression of EVI-1, and concurrent CSF3R and SETBP1 mutations: A case report". Oncology Letters 10.3 (2015): 1694-1700.
Chicago
Altangerel, O., Cao, S., Meng, J., Liu, P., Haiyan, G., Xu, Y., Zhao, M."Chronic neutrophilic leukemia with overexpression of EVI-1, and concurrent CSF3R and SETBP1 mutations: A case report". Oncology Letters 10, no. 3 (2015): 1694-1700. https://doi.org/10.3892/ol.2015.3485