SMAD4 expression in breast ductal carcinoma correlates with prognosis

  • Authors:
    • Nannan Liu
    • Chunyan Yu
    • Yanfen Shi
    • Jing Jiang
    • Yuhe Liu
  • View Affiliations

  • Published online on: July 1, 2015     https://doi.org/10.3892/ol.2015.3442
  • Pages: 1709-1715
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Abstract

The present study examined SMAD4 expression in fine‑needle aspiration cell blocks from patients with breast ductal carcinoma, in order to assess its viability as a prognostic marker. Using immunohistochemistry, the SMAD4 protein status of 86 breast ductal carcinoma fine-needle biopsies, from patients who underwent tumor resection at Beihua University Affiliated Hospital (Jilin, China) between 2002 and 2008, was characterized. The association between SMAD4 expression and clinicopathological parameters, as well as prognosis was assessed using the Mantel‑Haenszel method and Cox proportional hazards regression. SMAD4 staining was observed in the cytoplasm and nucleus, and its expression was found to be decreased in ductal breast carcinoma as compared with adjacent normal breast epithelia. Patients with reduced SMAD4 expression levels tended to exhibit more poorly differentiated tumors, a higher risk of recurrence and shorter overall survival. These results demonstrated that the evaluation of SMAD4 protein status in fine-needle biopsy specimens of breast ductal carcinoma may provide additional prognostic information.
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September-2015
Volume 10 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Liu N, Yu C, Shi Y, Jiang J and Liu Y: SMAD4 expression in breast ductal carcinoma correlates with prognosis. Oncol Lett 10: 1709-1715, 2015
APA
Liu, N., Yu, C., Shi, Y., Jiang, J., & Liu, Y. (2015). SMAD4 expression in breast ductal carcinoma correlates with prognosis. Oncology Letters, 10, 1709-1715. https://doi.org/10.3892/ol.2015.3442
MLA
Liu, N., Yu, C., Shi, Y., Jiang, J., Liu, Y."SMAD4 expression in breast ductal carcinoma correlates with prognosis". Oncology Letters 10.3 (2015): 1709-1715.
Chicago
Liu, N., Yu, C., Shi, Y., Jiang, J., Liu, Y."SMAD4 expression in breast ductal carcinoma correlates with prognosis". Oncology Letters 10, no. 3 (2015): 1709-1715. https://doi.org/10.3892/ol.2015.3442