Sentinel lymph node biopsy in patients with breast ductal carcinoma in situ: Chinese experiences

  • Authors:
    • Xiao Sun
    • Hao Li
    • Yan‑Bing Liu
    • Zheng‑Bo Zhou
    • Peng Chen
    • Tong Zhao
    • Chun‑Jian Wang
    • Zhao‑Peng Zhang
    • Peng‑Fei Qiu
    • Yong‑Sheng Wang
  • View Affiliations

  • Published online on: July 10, 2015     https://doi.org/10.3892/ol.2015.3480
  • Pages: 1932-1938
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Abstract

The axillary treatment of patients with ductal carcinoma in situ (DCIS) remains controversial. The aim of the present study was to evaluate the roles of sentinel lymph node biopsy (SLNB) in patients with breast DCIS. A database containing the data from 262 patients diagnosed with breast DCIS and 100 patients diagnosed with DCIS with microinvasion (DCISM) who received SLNB between January 2002 and July 2014 was retrospectively analyzed. Of the 262 patients with DCIS, 9 presented with SLN metastases (3 macrometastases and 6 micrometastases). Patients with large tumors diagnosed by ultrasound or with tumors of high histological grade had a higher positive rate of SLNs than those without (P=0.037 and P<0.0001, respectively). Of the 100 patients with DCISM, 11 presented with metastases. Younger patients had a higher positive rate of SLNs (P=0.028). According to the results of this study and the systematic review of recent studies, the indications of SLNB for patients with DCIS are as follows: SLNB should be performed in all DCISM patients and in those DCIS patients who received mastectomy, and could be avoided in those who received breast‑conserving surgery. However, SLNB should be recommended to patients who have high risks of harboring invasive components. The risk factors include a large, palpable tumor, a mammographic mass or a high histological grade.
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September-2015
Volume 10 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Sun X, Li H, Liu YB, Zhou ZB, Chen P, Zhao T, Wang CJ, Zhang ZP, Qiu PF, Wang YS, Wang YS, et al: Sentinel lymph node biopsy in patients with breast ductal carcinoma in situ: Chinese experiences. Oncol Lett 10: 1932-1938, 2015
APA
Sun, X., Li, H., Liu, Y., Zhou, Z., Chen, P., Zhao, T. ... Wang, Y. (2015). Sentinel lymph node biopsy in patients with breast ductal carcinoma in situ: Chinese experiences. Oncology Letters, 10, 1932-1938. https://doi.org/10.3892/ol.2015.3480
MLA
Sun, X., Li, H., Liu, Y., Zhou, Z., Chen, P., Zhao, T., Wang, C., Zhang, Z., Qiu, P., Wang, Y."Sentinel lymph node biopsy in patients with breast ductal carcinoma in situ: Chinese experiences". Oncology Letters 10.3 (2015): 1932-1938.
Chicago
Sun, X., Li, H., Liu, Y., Zhou, Z., Chen, P., Zhao, T., Wang, C., Zhang, Z., Qiu, P., Wang, Y."Sentinel lymph node biopsy in patients with breast ductal carcinoma in situ: Chinese experiences". Oncology Letters 10, no. 3 (2015): 1932-1938. https://doi.org/10.3892/ol.2015.3480