Open Access

Primary skeletal muscle diffuse large B cell lymphoma: A case report and review of the literature

  • Authors:
    • Lijuan Zhang
    • Quande Lin
    • Lina Zhang
    • Lihua Dong
    • Yufu Li
  • View Affiliations

  • Published online on: July 17, 2015     https://doi.org/10.3892/ol.2015.3505
  • Pages: 2156-2160
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The occurrence of primary extranodal non-Hodgkin's lymphoma (NHL) of soft tissue is rare, particularly in skeletal muscle. The present study describes a case of diffuse large B cell lymphoma of the right lower extremity and provides a detailed review of the literature associated with this disorder, with the aim of improving the future diagnosis and therapy of extranodal NHL. The present case report was of a 76‑year‑old woman who presented with a right thigh and calf mass. In view of the tumor's location and the patient's age, soft tissue tumors were considered to be soft tissue sarcoma. Imaging scans were performed to determine the location and size of the tumor, followed by a biopsy of the muscle. Histopathological examination then yielded a diagnosis of diffuse large B cell lymphoma. The patient then underwent 4 cycles of chemotherapy. There was evident relief of pain and swelling in the right extremity; however, positron emission tomography/computed tomography (PET/CT) determined insufficient treatment efficacy. Chemotherapy was adjusted for 2 cycles; however, the patient suffered an aggravation of edema, so a different chemotherapy regimen of bleomycin, cytarabine, vincristine, cyclosphamide and dexamethasone (BCOAD) was performed for a further 2 cycles. The edema was alleviated and magnetic resonance imaging revealed shrinkage of the lower limb mass and the right thigh mass was undetectable. In conclusion, the present case report demonstrated that PET/CT may help determine the efficacy of chemotherapy treatment and that the BCOAD chemotherapy regimen may be more effective than standard treatments in certain cases.
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October-2015
Volume 10 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhang L, Lin Q, Zhang L, Dong L and Li Y: Primary skeletal muscle diffuse large B cell lymphoma: A case report and review of the literature. Oncol Lett 10: 2156-2160, 2015
APA
Zhang, L., Lin, Q., Zhang, L., Dong, L., & Li, Y. (2015). Primary skeletal muscle diffuse large B cell lymphoma: A case report and review of the literature. Oncology Letters, 10, 2156-2160. https://doi.org/10.3892/ol.2015.3505
MLA
Zhang, L., Lin, Q., Zhang, L., Dong, L., Li, Y."Primary skeletal muscle diffuse large B cell lymphoma: A case report and review of the literature". Oncology Letters 10.4 (2015): 2156-2160.
Chicago
Zhang, L., Lin, Q., Zhang, L., Dong, L., Li, Y."Primary skeletal muscle diffuse large B cell lymphoma: A case report and review of the literature". Oncology Letters 10, no. 4 (2015): 2156-2160. https://doi.org/10.3892/ol.2015.3505