Clinicopathological features of dermatofibrosarcoma protuberans

  • Authors:
    • Noppadol Larbcharoensub
    • Jitchai Kayankarnnavee
    • Suda Sanpaphant
    • Kidakorn Kiranantawat
    • Chewarat Wirojtananugoon
    • Vorachai Sirikulchayanonta
  • View Affiliations

  • Published online on: November 24, 2015     https://doi.org/10.3892/ol.2015.3966
  • Pages: 661-667
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Abstract

Dermatofibrosarcoma protuberans (DFSP) is a superficial cutaneous tumor of low malignant potential characterized by a high rate of local recurrence. The histopathological appearance shows uniform spindle neoplastic cells arranged in a predominantly storiform pattern, typically with positive staining for cluster of differentiation (CD)34 and vimentin on immunohistochemistry. A minority of cases of DFSP have areas of sarcomatous transformation. Wide surgical excision is the cornerstone of treatment for DFSP. The objective of the present study was to determine the clinicopathological features of DFSP. Pathological records were searched for cases of DFSP in the database of the Department of Pathology, Faculty of Medicine Ramathibodi Hospital (Mahidol University, Bangkok, Thailand) between 1994 and 2013. The results showed 68 cases with DFSP. The mean age at diagnosis was 40 years (range, 3‑86 years). Among this group of patients, 26 cases (38.2%) experienced local recurrence and 6 (8.8%) exhibited sarcomatous transformation of DFSP. The factors that predict the recurrence of DFSP are an incorrect first pathological diagnosis and an inadequate surgical margin. The factors that predict the sarcomatous transformation of DFSP are a larger tumor size and an incorrect first pathological diagnosis. In patients who have tumors with spindle cells arranged in a storiform pattern, CD34 immunohistochemical staining provides the definitive diagnosis. Exact histopathological categorization is important to select the appropriate treatment and predict the clinical outcome.
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January-2016
Volume 11 Issue 1

Print ISSN: 1792-1074
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Spandidos Publications style
Larbcharoensub N, Kayankarnnavee J, Sanpaphant S, Kiranantawat K, Wirojtananugoon C and Sirikulchayanonta V: Clinicopathological features of dermatofibrosarcoma protuberans. Oncol Lett 11: 661-667, 2016
APA
Larbcharoensub, N., Kayankarnnavee, J., Sanpaphant, S., Kiranantawat, K., Wirojtananugoon, C., & Sirikulchayanonta, V. (2016). Clinicopathological features of dermatofibrosarcoma protuberans. Oncology Letters, 11, 661-667. https://doi.org/10.3892/ol.2015.3966
MLA
Larbcharoensub, N., Kayankarnnavee, J., Sanpaphant, S., Kiranantawat, K., Wirojtananugoon, C., Sirikulchayanonta, V."Clinicopathological features of dermatofibrosarcoma protuberans". Oncology Letters 11.1 (2016): 661-667.
Chicago
Larbcharoensub, N., Kayankarnnavee, J., Sanpaphant, S., Kiranantawat, K., Wirojtananugoon, C., Sirikulchayanonta, V."Clinicopathological features of dermatofibrosarcoma protuberans". Oncology Letters 11, no. 1 (2016): 661-667. https://doi.org/10.3892/ol.2015.3966