Pantoprazole inhibits human gastric adenocarcinoma SGC-7901 cells by downregulating the expression of pyruvate kinase M2

  • Authors:
    • Yonghua Shen
    • Min Chen
    • Shuling Huang
    • Xiaoping Zou
  • View Affiliations

  • Published online on: November 13, 2015     https://doi.org/10.3892/ol.2015.3912
  • Pages: 717-722
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Abstract

The Warburg effect is important in tumor growth. The human M2 isoform of pyruvate kinase (PKM2) is a key enzyme that regulates aerobic glycolysis in tumor cells. Recent studies have demonstrated that PKM2 is a potential target for cancer therapy. The present study investigated the effects of pantoprazole (PPZ) treatment and PKM2 transfection on human gastric adenocarcinoma SGC‑7901 cells in vitro. The present study revealed that PPZ inhibited the proliferation of tumor cells, induced apoptosis and downregulated the expression of PKM2, which contributes to the current understanding of the functional association between PPZ and PKM2. In summary, PPZ may suppress tumor growth as a PKM2 protein inhibitor.
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January-2016
Volume 11 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Shen Y, Chen M, Huang S and Zou X: Pantoprazole inhibits human gastric adenocarcinoma SGC-7901 cells by downregulating the expression of pyruvate kinase M2. Oncol Lett 11: 717-722, 2016
APA
Shen, Y., Chen, M., Huang, S., & Zou, X. (2016). Pantoprazole inhibits human gastric adenocarcinoma SGC-7901 cells by downregulating the expression of pyruvate kinase M2. Oncology Letters, 11, 717-722. https://doi.org/10.3892/ol.2015.3912
MLA
Shen, Y., Chen, M., Huang, S., Zou, X."Pantoprazole inhibits human gastric adenocarcinoma SGC-7901 cells by downregulating the expression of pyruvate kinase M2". Oncology Letters 11.1 (2016): 717-722.
Chicago
Shen, Y., Chen, M., Huang, S., Zou, X."Pantoprazole inhibits human gastric adenocarcinoma SGC-7901 cells by downregulating the expression of pyruvate kinase M2". Oncology Letters 11, no. 1 (2016): 717-722. https://doi.org/10.3892/ol.2015.3912