MicroRNA‑205 increases the sensitivity of docetaxel in breast cancer

  • Authors:
    • Yang Cai
    • Xiang Yan
    • Guoqing Zhang
    • Weihong Zhao
    • Shunchang Jiao
  • View Affiliations

  • Published online on: December 11, 2015     https://doi.org/10.3892/ol.2015.4030
  • Pages: 1105-1109
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Chemotherapy has been widely used in breast cancer therapy, but the efficacy of chemotherapy is intimately associated with the sensitivity of therapeutic drugs to breast cancer. Docetaxel is a first‑line chemotherapeutic drug in breast cancer treatment, but further improvement to its efficacy has thus far proved difficult. microRNAs (miRs) are a class of endogenous, small, non‑coding RNAs, which regulate gene expression at the post‑transcriptional level. miR‑205, a regulator of HER‑3, is reported to be a tumor suppressor in breast cancer. In the present study, the reintroduction of miR‑205 is shown to inhibit cell proliferation and clonogenic potential, and increase the sensitivity of MCF‑7 and MDA‑MB‑231 cells to docetaxel. miR‑205 also shows a synergistic effect with docetaxel in vivo. The present study provides a novel strategy to increase the sensitivity to docetaxel in breast cancer patients.
View Figures
View References

Related Articles

Journal Cover

February-2016
Volume 11 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Cai Y, Yan X, Zhang G, Zhao W and Jiao S: MicroRNA‑205 increases the sensitivity of docetaxel in breast cancer. Oncol Lett 11: 1105-1109, 2016
APA
Cai, Y., Yan, X., Zhang, G., Zhao, W., & Jiao, S. (2016). MicroRNA‑205 increases the sensitivity of docetaxel in breast cancer. Oncology Letters, 11, 1105-1109. https://doi.org/10.3892/ol.2015.4030
MLA
Cai, Y., Yan, X., Zhang, G., Zhao, W., Jiao, S."MicroRNA‑205 increases the sensitivity of docetaxel in breast cancer". Oncology Letters 11.2 (2016): 1105-1109.
Chicago
Cai, Y., Yan, X., Zhang, G., Zhao, W., Jiao, S."MicroRNA‑205 increases the sensitivity of docetaxel in breast cancer". Oncology Letters 11, no. 2 (2016): 1105-1109. https://doi.org/10.3892/ol.2015.4030