Open Access

Primary Sjögren's syndrome initially presenting as submandibular mucosa-associated lymphoid tissue lymphoma: A case report

  • Authors:
    • Liang‑Yu Chen
    • Ming‑Hsui Tsai
    • Li‑Tai Tsai
    • Hsin‑Man Lu
    • Chia‑Ing Jan
  • View Affiliations

  • Published online on: November 30, 2015     https://doi.org/10.3892/ol.2015.3980
  • Pages: 921-924
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study reports the case of a 24-year-old female affected with primary Sjögren's syndrome (pSS), who presented with mucosa‑associated lymphoid tissue (MALT) lymphoma of the submandibular gland. Reports of such cases, particularly in young patients, are very rare. The patient, who presented no oral or ocular symptoms prior to the development of the mass, underwent surgical ablation of the gland, and MALT lymphoma was diagnosed by histopathology. Since MALT lymphoma in the submandibular gland is rarely observed in otherwise healthy young females, a rheumatologist and an oncologist were consulted. Following a number of immunological tests, the results of the Schirmer's and Saxon tests were negative. However, the antinuclear antibody test revealed a speckled appearance, and there was also strong positivity for the serological markers of Sjögren's syndrome. Consequently, pSS was diagnosed, despite the fact that the patient did not fulfill all the diagnostic criteria for the disease. Therefore, MALT lymphoma in a single salivary gland should be used as a differential diagnosis for Sjögren's syndrome in young asymptomatic patients. Additionally, a multidisciplinary team is required for the treatment and management of these patients.
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February-2016
Volume 11 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Chen LY, Tsai MH, Tsai LT, Lu HM and Jan CI: Primary Sjögren's syndrome initially presenting as submandibular mucosa-associated lymphoid tissue lymphoma: A case report. Oncol Lett 11: 921-924, 2016
APA
Chen, L., Tsai, M., Tsai, L., Lu, H., & Jan, C. (2016). Primary Sjögren's syndrome initially presenting as submandibular mucosa-associated lymphoid tissue lymphoma: A case report. Oncology Letters, 11, 921-924. https://doi.org/10.3892/ol.2015.3980
MLA
Chen, L., Tsai, M., Tsai, L., Lu, H., Jan, C."Primary Sjögren's syndrome initially presenting as submandibular mucosa-associated lymphoid tissue lymphoma: A case report". Oncology Letters 11.2 (2016): 921-924.
Chicago
Chen, L., Tsai, M., Tsai, L., Lu, H., Jan, C."Primary Sjögren's syndrome initially presenting as submandibular mucosa-associated lymphoid tissue lymphoma: A case report". Oncology Letters 11, no. 2 (2016): 921-924. https://doi.org/10.3892/ol.2015.3980