Open Access

Low-grade myofibroblastic sarcomas of the maxilla

  • Authors:
    • Jin-Yu Qiu
    • Peng Liu
    • Ce Shi
    • Bing Han
  • View Affiliations

  • Published online on: December 11, 2014     https://doi.org/10.3892/ol.2014.2790
  • Pages: 619-625
  • Copyright: © Qiu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Low‑grade myofibroblastic sarcoma (LGMS) is a distinct mesenchymal myofibroblastic malignancy. The tumor may occur at a variety of sites, but is particularly associated with the head and neck. Of the two maxillary sarcomas that were analyzed in the present study, one was misdiagnosed as an inflammatory myofibroblastic tumor during pre‑operative excision biopsy, and later presented with a different immunophenotype upon recurrence. Representative paraffin blocks from formalin‑fixed tissues were selected from each patient and designated as case 1 and case 2. Immunohistochemical studies were performed on 3‑µm thick sections using primary antibodies against α‑smooth muscle actin (α‑SMA), muscle‑specific actin (MSA), desmin, vimentin, calponin, h‑caldesmon, fibronectin, cytokeratin, cluster of differentiation 34 (CD34), S‑100 protein, anaplastic lymphoma kinase (ALK), epithelial membrane antigen (EMA) and Ki‑67. Immunohistochemistry was performed using the streptavidin‑biotin‑peroxidase complex method. The tumor cells from the two maxillary LGMSs, including the recurrent lesion, were positive for vimentin and fibronectin, and negative for S‑100 protein, CD34, EMA, h‑caldesmon, ALK, MSA and calponin. The tumor cells from case 1 demonstrated positive staining for α‑SMA protein and negative staining for desmin. By contrast, the tumor cells from the primary lesion in case 2 presented with negative staining for α‑SMA and positive staining for desmin, while the cells of the recurrent lesion were α‑SMA‑positive and desmin‑negative. The present study concluded that cases of LGMS with immunoprofile alterations are predictive of relatively poor prognoses.
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February-2015
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Spandidos Publications style
Qiu J, Liu P, Shi C and Han B: Low-grade myofibroblastic sarcomas of the maxilla. Oncol Lett 9: 619-625, 2015
APA
Qiu, J., Liu, P., Shi, C., & Han, B. (2015). Low-grade myofibroblastic sarcomas of the maxilla. Oncology Letters, 9, 619-625. https://doi.org/10.3892/ol.2014.2790
MLA
Qiu, J., Liu, P., Shi, C., Han, B."Low-grade myofibroblastic sarcomas of the maxilla". Oncology Letters 9.2 (2015): 619-625.
Chicago
Qiu, J., Liu, P., Shi, C., Han, B."Low-grade myofibroblastic sarcomas of the maxilla". Oncology Letters 9, no. 2 (2015): 619-625. https://doi.org/10.3892/ol.2014.2790