Open Access

Clinical and histopathological factors associated with Ki-67 expression in breast cancer patients

  • Authors:
    • Gul Alco
    • Atilla Bozdogan
    • Derya Selamoglu
    • Kezban Nur Pilancı
    • Sıtkı Tuzlalı
    • Cetin Ordu
    • Sefik Igdem
    • Sait Okkan
    • Maktav Dincer
    • Gokhan Demir
    • Vahit Ozmen
  • View Affiliations

  • Published online on: January 7, 2015     https://doi.org/10.3892/ol.2015.2852
  • Pages: 1046-1054
  • Copyright: © Alco et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to identify the optimal Ki-67 cut-off value in breast cancer (BC) patients, and investigate the association of Ki‑67 expression levels with other prognostic factors. Firstly, a retrospective search was performed to identify patients with stage I-III BC (n=462). A range of Ki-67 index values were then assigned to five groups (<10, 10-14, 15-19, 20-24 and ≥25%). The correlation between the Ki-67 index and other prognostic factors [age, tumor type, histological and nuclear grade, tumor size, multifocality, an in situ component, lymphovascular invasion (LVI), estrogen and progesterone receptor (ER/PR) expression, human epidermal growth factor receptor (HER-2) status, axillary involvement and tumor stage] were investigated in each group. The median Ki-67 value was revealed to be 20% (range, 1-95%). A young age (≤40 years old), tumor type, size and grade, LVI, ER/PR negativity and HER-2 positivity were revealed to be associated with the Ki-67 level. Furthermore, Ki-67 was demonstrated to be negatively correlated with ER/PR expression (P<0.001), but positively correlated with tumor size (P<0.001). The multivariate analysis revealed that a Ki-67 value of ≥15% was associated with the largest number of poor prognostic factors (P=0.036). In addition, a Ki-67 value of ≥15% was identified to be statistically significant in association with certain luminal subtypes. The rate of disease‑free survival was higher in patients with luminal A subtype BC (P=0.036). Following the correlation analysis for the Ki-67 index and the other prognostic factors, a Ki-67 value of ≥15% was revealed to be the optimal cut-off level for BC patients.
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March-2015
Volume 9 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Alco G, Bozdogan A, Selamoglu D, Pilancı KN, Tuzlalı S, Ordu C, Igdem S, Okkan S, Dincer M, Demir G, Demir G, et al: Clinical and histopathological factors associated with Ki-67 expression in breast cancer patients. Oncol Lett 9: 1046-1054, 2015
APA
Alco, G., Bozdogan, A., Selamoglu, D., Pilancı, K.N., Tuzlalı, S., Ordu, C. ... Ozmen, V. (2015). Clinical and histopathological factors associated with Ki-67 expression in breast cancer patients. Oncology Letters, 9, 1046-1054. https://doi.org/10.3892/ol.2015.2852
MLA
Alco, G., Bozdogan, A., Selamoglu, D., Pilancı, K. N., Tuzlalı, S., Ordu, C., Igdem, S., Okkan, S., Dincer, M., Demir, G., Ozmen, V."Clinical and histopathological factors associated with Ki-67 expression in breast cancer patients". Oncology Letters 9.3 (2015): 1046-1054.
Chicago
Alco, G., Bozdogan, A., Selamoglu, D., Pilancı, K. N., Tuzlalı, S., Ordu, C., Igdem, S., Okkan, S., Dincer, M., Demir, G., Ozmen, V."Clinical and histopathological factors associated with Ki-67 expression in breast cancer patients". Oncology Letters 9, no. 3 (2015): 1046-1054. https://doi.org/10.3892/ol.2015.2852