Upregulation of the B7/CD28 family member B7-H3 in bladder cancer

  • Authors:
    • Deyao Wu
    • Zichun Zhang
    • Huixing Pan
    • Yuanfeng Fan
    • Ping Qu
    • Jian Zhou
  • View Affiliations

  • Published online on: December 23, 2014     https://doi.org/10.3892/ol.2014.2828
  • Pages: 1420-1424
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Abstract

Dysregulation of B7‑H3 has been observed in a variety of types of human cancers. In the present study, the mRNA expression level of B7‑H3 was analyzed in bladder cancer by performing semi‑quantitative reverse transcription‑polymerase chain reaction on clinical specimens from transitional cell carcinomas (TCCs) and their normal adjacent tissues (NATs). Immunohistochemical analysis was performed to compare the protein expression level of B7‑H3 in TCCs and the paired NATs. The present study indicated that the B7‑H3 mRNA expression level was significantly higher in the TCC samples compared with the paired NAT samples. Furthermore, immunohistochemical analyses indicated that the B7‑H3 protein expression level was significantly upregulated in the TCC samples compared with in the paired NAT samples, indicating that B7‑H3 dysregulation may be important in the progression of bladder cancer.
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March-2015
Volume 9 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Wu D, Zhang Z, Pan H, Fan Y, Qu P and Zhou J: Upregulation of the B7/CD28 family member B7-H3 in bladder cancer. Oncol Lett 9: 1420-1424, 2015
APA
Wu, D., Zhang, Z., Pan, H., Fan, Y., Qu, P., & Zhou, J. (2015). Upregulation of the B7/CD28 family member B7-H3 in bladder cancer. Oncology Letters, 9, 1420-1424. https://doi.org/10.3892/ol.2014.2828
MLA
Wu, D., Zhang, Z., Pan, H., Fan, Y., Qu, P., Zhou, J."Upregulation of the B7/CD28 family member B7-H3 in bladder cancer". Oncology Letters 9.3 (2015): 1420-1424.
Chicago
Wu, D., Zhang, Z., Pan, H., Fan, Y., Qu, P., Zhou, J."Upregulation of the B7/CD28 family member B7-H3 in bladder cancer". Oncology Letters 9, no. 3 (2015): 1420-1424. https://doi.org/10.3892/ol.2014.2828