Association between polymorphisms in the promoter region of T cell immunoglobulin and mucin domain-3 and myasthenia gravis-associated thymoma

  • Authors:
    • Guowu Xu
    • Kai Zheng
    • Xing Lu
    • Jinxiang Wang
    • Yanfen Chai
    • Junyi Wang
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  • Published online on: January 5, 2015     https://doi.org/10.3892/ol.2015.2845
  • Pages: 1470-1474
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Abstract

Thymoma is a type of benign or low‑grade malignant tumor, occurring on the thymic epithelium. Patients with thymoma may also suffer from myasthenia gravis (MG), presenting MG‑associated thymoma. T cell immunoglobulin and mucin domain‑3 (Tim‑3), a subtype of the Tim protein family, may be an important immune regulatory and pivotal molecule associated with tumor development. In order to understand the etiology and pathogenesis of MG‑associated thymoma in the Han population of North China, the present study investigated the association between a polymorphism on the ‑574 locus in the promoter of Tim‑3 and the risk of MG‑associated thymoma in the Han Chinese population. In total, 116 patients with thymoma and MG were enrolled into the MG‑associated thymoma group, while 124 patients with thymoma, but without MG, were enrolled into the non‑MG‑associated thymoma group. Examinations were conducted to reach a definite diagnosis of thymoma and MG and rule out other autoimmune diseases. Allele‑specific polymerase chain reaction (AS‑PCR) was performed to determine the polymorphism on the ‑574 locus of Tim‑3 in all the subjects. PCR products were randomly selected for sequencing. Statistically significant differences were detected between the distribution frequencies of the GT+TT genotype and T allele on the ‑574 locus of the MG‑associated thymoma group (31.03 vs. 12.90%, respectively; χ2=11.609, P=0.001) and the non‑MG‑associated thymoma group (15.52 vs. 6.45%, respectively; χ2=10.198, P=0.001). In conclusion, the present study indicated that an association may exist between the polymorphism of the ‑574 locus in the Tim‑3 promoter and MG‑associated thymoma.
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March-2015
Volume 9 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Xu G, Zheng K, Lu X, Wang J, Chai Y and Wang J: Association between polymorphisms in the promoter region of T cell immunoglobulin and mucin domain-3 and myasthenia gravis-associated thymoma. Oncol Lett 9: 1470-1474, 2015
APA
Xu, G., Zheng, K., Lu, X., Wang, J., Chai, Y., & Wang, J. (2015). Association between polymorphisms in the promoter region of T cell immunoglobulin and mucin domain-3 and myasthenia gravis-associated thymoma. Oncology Letters, 9, 1470-1474. https://doi.org/10.3892/ol.2015.2845
MLA
Xu, G., Zheng, K., Lu, X., Wang, J., Chai, Y., Wang, J."Association between polymorphisms in the promoter region of T cell immunoglobulin and mucin domain-3 and myasthenia gravis-associated thymoma". Oncology Letters 9.3 (2015): 1470-1474.
Chicago
Xu, G., Zheng, K., Lu, X., Wang, J., Chai, Y., Wang, J."Association between polymorphisms in the promoter region of T cell immunoglobulin and mucin domain-3 and myasthenia gravis-associated thymoma". Oncology Letters 9, no. 3 (2015): 1470-1474. https://doi.org/10.3892/ol.2015.2845