Open Access

Stereotactic aspiration combined with gamma knife radiosurgery for the treatment of cystic brainstem metastasis originating from lung adenosquamous carcinoma: A case report

  • Authors:
    • Chao Du
    • Zhaohui Li
    • Zhijia Wang
    • Liping Wang
    • Yu Tian
  • View Affiliations

  • Published online on: February 16, 2015     https://doi.org/10.3892/ol.2015.2968
  • Pages: 1607-1613
  • Copyright: © Du et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Brainstem metastases have a poor prognosis and are difficult to manage. The present study describes the first case of histopathologically‑confirmed brainstem metastasis originating from lung adenosquamous carcinoma, and discusses the outcomes of treatment by stereotactic aspiration combined with gamma knife radiosurgery (GKRS). A 59‑year‑old female presented with a cystic mass (15x12x13 mm; volume, 1.3 cm3) located in the pons, two years following surgical treatment for adenosquamous carcinoma of the lung. The patient received initial GKRS for the lesion in the pons with a total dose of 54.0 Gy, however, the volume of the mass subsequently increased to 3.9 cm3 over a period of three months. Computed tomography‑guided stereotactic biopsy and aspiration of the intratumoral cyst were performed, yielding 2.0 cm3 of yellow‑white fluid. Histology confirmed the diagnosis of adenosquamous carcinoma. Aspiration provided immediate symptomatic relief, and was followed one week later by repeat GKRS with a dose of 12.0 Gy. The patient survived for 12 months following the repeat GKRS; however, later succumbed to the disease after lapsing into a two‑week coma. The findings of this case suggest that stereotactic aspiration of cysts may improve the effects of GKRS for the treatment of cystic brainstem metastasis; the decrease in tumor volume allowed a higher radiation dose to be administered with a lower risk of radiation‑induced side effects. Therefore, stereotactic aspiration combined with GKRS may be an effective treatment for brainstem metastasis originating from adenosquamous carcinoma.
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April-2015
Volume 9 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Du C, Li Z, Wang Z, Wang L and Tian Y: Stereotactic aspiration combined with gamma knife radiosurgery for the treatment of cystic brainstem metastasis originating from lung adenosquamous carcinoma: A case report. Oncol Lett 9: 1607-1613, 2015
APA
Du, C., Li, Z., Wang, Z., Wang, L., & Tian, Y. (2015). Stereotactic aspiration combined with gamma knife radiosurgery for the treatment of cystic brainstem metastasis originating from lung adenosquamous carcinoma: A case report. Oncology Letters, 9, 1607-1613. https://doi.org/10.3892/ol.2015.2968
MLA
Du, C., Li, Z., Wang, Z., Wang, L., Tian, Y."Stereotactic aspiration combined with gamma knife radiosurgery for the treatment of cystic brainstem metastasis originating from lung adenosquamous carcinoma: A case report". Oncology Letters 9.4 (2015): 1607-1613.
Chicago
Du, C., Li, Z., Wang, Z., Wang, L., Tian, Y."Stereotactic aspiration combined with gamma knife radiosurgery for the treatment of cystic brainstem metastasis originating from lung adenosquamous carcinoma: A case report". Oncology Letters 9, no. 4 (2015): 1607-1613. https://doi.org/10.3892/ol.2015.2968