MicroRNA-125b suppresses the migration and invasion of hepatocellular carcinoma cells by targeting transcriptional coactivator with PDZ-binding motif

  • Authors:
    • Jipeng Li
    • Laifu Fang
    • Wanjun Yu
    • Yiping Wang
  • View Affiliations

  • Published online on: February 17, 2015     https://doi.org/10.3892/ol.2015.2973
  • Pages: 1971-1975
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Abstract

MicroRNAs (miRNAs) are a class of small non‑coding RNA molecules that serve an important function in carcinogenesis and tumor progression. The present study investigated the roles and mechanisms of miRNA‑125b (miR‑125b) in human hepatocellular carcinoma (HCC). miR‑125b was significantly downregulated in the examined HCC tissues and cell lines. Overexpression of miR‑125b reduced HCC cell migration and invasion. By contrast, inhibition of miR‑125b expression significantly accelerated HCC cell migration and invasion. In addition, the present study identified transcriptional coactivator with PDZ‑binding motif (TAZ) as a functional downstream target of miR‑125b. Furthermore, overexpression of TAZ impaired miR‑125b‑induced inhibition of invasion in HCC cells. The current study demonstrated that miR‑125b may be involved in the tumorigenesis of HCC at least in part by the suppression of TAZ.
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April-2015
Volume 9 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Li J, Fang L, Yu W and Wang Y: MicroRNA-125b suppresses the migration and invasion of hepatocellular carcinoma cells by targeting transcriptional coactivator with PDZ-binding motif. Oncol Lett 9: 1971-1975, 2015
APA
Li, J., Fang, L., Yu, W., & Wang, Y. (2015). MicroRNA-125b suppresses the migration and invasion of hepatocellular carcinoma cells by targeting transcriptional coactivator with PDZ-binding motif. Oncology Letters, 9, 1971-1975. https://doi.org/10.3892/ol.2015.2973
MLA
Li, J., Fang, L., Yu, W., Wang, Y."MicroRNA-125b suppresses the migration and invasion of hepatocellular carcinoma cells by targeting transcriptional coactivator with PDZ-binding motif". Oncology Letters 9.4 (2015): 1971-1975.
Chicago
Li, J., Fang, L., Yu, W., Wang, Y."MicroRNA-125b suppresses the migration and invasion of hepatocellular carcinoma cells by targeting transcriptional coactivator with PDZ-binding motif". Oncology Letters 9, no. 4 (2015): 1971-1975. https://doi.org/10.3892/ol.2015.2973