Surface-enhanced laser desorption ionization time-of-flight mass spectrometry used to screen serum diagnostic markers of colon cancer recurrence in situ following surgery

  • Authors:
    • Zhong‑Yin Zhou
    • Tuo Ji
    • He‑Sheng Luo
  • View Affiliations

  • Published online on: February 26, 2015     https://doi.org/10.3892/ol.2015.2987
  • Pages: 2313-2316
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Abstract

The aim of the present study was to identify specific serum biomarkers in patients with colon cancer recurrence in situ following surgery. The study was conducted at the Renmin Hospital of Wuhan University (Wuhan, China) between January 2012 and January 2014. Surface‑enhanced laser desorption ionization time‑of‑flight mass spectrometry was used to compare and analyze the serum protein profiles of patients with (n=50) and patients without (n=50) recurrence in situ. Biomarker Wizard software was used to analyze and obtain the protein spectrum. In total, nine protein peaks demonstrated statistically significant differences between the recurrence and non‑recurrence group (P<0.05), which included two protein peaks (7,731.3 Da and 8,266.5 Da). The two protein peaks were highly expressed in patients with colon cancer recurrence in situ following surgery, but lowly expressed in patients without recurrence. Therefore, the two protein peaks may represent potential biomarkers for the prediction of colon cancer recurrence in situ following surgical treatment.
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May-2015
Volume 9 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhou ZY, Ji T and Luo HS: Surface-enhanced laser desorption ionization time-of-flight mass spectrometry used to screen serum diagnostic markers of colon cancer recurrence in situ following surgery. Oncol Lett 9: 2313-2316, 2015
APA
Zhou, Z., Ji, T., & Luo, H. (2015). Surface-enhanced laser desorption ionization time-of-flight mass spectrometry used to screen serum diagnostic markers of colon cancer recurrence in situ following surgery. Oncology Letters, 9, 2313-2316. https://doi.org/10.3892/ol.2015.2987
MLA
Zhou, Z., Ji, T., Luo, H."Surface-enhanced laser desorption ionization time-of-flight mass spectrometry used to screen serum diagnostic markers of colon cancer recurrence in situ following surgery". Oncology Letters 9.5 (2015): 2313-2316.
Chicago
Zhou, Z., Ji, T., Luo, H."Surface-enhanced laser desorption ionization time-of-flight mass spectrometry used to screen serum diagnostic markers of colon cancer recurrence in situ following surgery". Oncology Letters 9, no. 5 (2015): 2313-2316. https://doi.org/10.3892/ol.2015.2987