PROGNOSTIC VALUE OF UROKINASE-TYPE PLASMINOGEN ACTIVATORS IN GASTRIC-CANCER

  • Authors: Y YONEMURA, I NINOMIYA, N NOJIMA, K SUGIYAMA, T FUJIMURA, K TSUCHIHARA, T KAWAMURA, M KAJI, I MIYAZAKI, Y ENDO, M TANAKA, T SASAKI
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  • Published online on: Friday, July 1, 1994
  • Pages: 765-772
  • DOI: 10.3892/or.1.4.765

Abstract

To elucidate the relation between urokinase-type plasminogen activator (U-PA) and metastasis in gastric cancer, we examined U-PA tissue status immunohistochemically. Ninety-eight primary gastric cancer, prepared by AMeX method, were analyzed with anti-U-PA and anti-proliferating cell nuclear antigen (PCNA) monoclonal antibody. In addition, DNA ploidy patterns were determined by cytofluorometer after staining with propidium iodide. U-PA immunoreactivity can be observed as diffuse cytoplasmic staining, as intensely outlined luminal borders or in desquameted cells in the lumens. U-PA expression-positive tumors showed higher incidence of serosal invasion, lymph node involvement or larger tumors than did U-PA negative ones. There was no correlation between U-PA tissue status and PCNA labeling rates or DNA ploidy patterns. Patients with a U-PA positive tumor survived significantly shorter than those with U-PA negative ones. These results may indicate that U-PA tissue status is a useful biological prognostic indicator in gastric cancer. The high malignant potential of U-PA positive tumors may be associated with a rapid infiltrating capacity through gastric wall but not with a high proliferative activity.
Journal Cover

July 1994
Volume 1 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

2013 Impact Factor: 2.191
Ranked #33/202 Oncology
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APA
YONEMURA, Y., NINOMIYA, I., NOJIMA, N., SUGIYAMA, K., FUJIMURA, T., TSUCHIHARA, K., KAWAMURA, T., KAJI, M., MIYAZAKI, I., ENDO, Y., TANAKA, M., & SASAKI, T. (1994). PROGNOSTIC VALUE OF UROKINASE-TYPE PLASMINOGEN ACTIVATORS IN GASTRIC-CANCER. Oncology Reports, 1(4), 765-772.
MLA
YONEMURA, NINOMIYA, NOJIMA, SUGIYAMA, FUJIMURA, TSUCHIHARA, KAWAMURA, KAJI, MIYAZAKI, ENDO, TANAKA, and T SASAKI. "PROGNOSTIC VALUE OF UROKINASE-TYPE PLASMINOGEN ACTIVATORS IN GASTRIC-CANCER." Oncology Reports Oncology Reports 1.4 (1994): 765-772.
Chicago
YONEMURA, NINOMIYA, NOJIMA, SUGIYAMA, FUJIMURA, TSUCHIHARA, KAWAMURA, KAJI, MIYAZAKI, ENDO, TANAKA, and T SASAKI. "PROGNOSTIC VALUE OF UROKINASE-TYPE PLASMINOGEN ACTIVATORS IN GASTRIC-CANCER." Oncology Reports Oncology Reports 1 no. 4 (1994): 765-772.