PROGNOSTIC VALUE OF UROKINASE-TYPE PLASMINOGEN ACTIVATORS IN GASTRIC-CANCER

  • Authors:
    • Y YONEMURA
    • I NINOMIYA
    • N NOJIMA
    • K SUGIYAMA
    • T FUJIMURA
    • K TSUCHIHARA
    • T KAWAMURA
    • M KAJI
    • I MIYAZAKI
    • Y ENDO
    • M TANAKA
    • T SASAKI
  • View Affiliations

  • Published online on: July 1, 1994     https://doi.org/10.3892/or.1.4.765
  • Pages: 765-772
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Abstract

To elucidate the relation between urokinase-type plasminogen activator (U-PA) and metastasis in gastric cancer, we examined U-PA tissue status immunohistochemically. Ninety-eight primary gastric cancer, prepared by AMeX method, were analyzed with anti-U-PA and anti-proliferating cell nuclear antigen (PCNA) monoclonal antibody. In addition, DNA ploidy patterns were determined by cytofluorometer after staining with propidium iodide. U-PA immunoreactivity can be observed as diffuse cytoplasmic staining, as intensely outlined luminal borders or in desquameted cells in the lumens. U-PA expression-positive tumors showed higher incidence of serosal invasion, lymph node involvement or larger tumors than did U-PA negative ones. There was no correlation between U-PA tissue status and PCNA labeling rates or DNA ploidy patterns. Patients with a U-PA positive tumor survived significantly shorter than those with U-PA negative ones. These results may indicate that U-PA tissue status is a useful biological prognostic indicator in gastric cancer. The high malignant potential of U-PA positive tumors may be associated with a rapid infiltrating capacity through gastric wall but not with a high proliferative activity.

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July 1994
Volume 1 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
YONEMURA Y, NINOMIYA I, NOJIMA N, SUGIYAMA K, FUJIMURA T, TSUCHIHARA K, KAWAMURA T, KAJI M, MIYAZAKI I, ENDO Y, ENDO Y, et al: PROGNOSTIC VALUE OF UROKINASE-TYPE PLASMINOGEN ACTIVATORS IN GASTRIC-CANCER. Oncol Rep 1: 765-772, 1994
APA
YONEMURA, Y., NINOMIYA, I., NOJIMA, N., SUGIYAMA, K., FUJIMURA, T., TSUCHIHARA, K. ... SASAKI, T. (1994). PROGNOSTIC VALUE OF UROKINASE-TYPE PLASMINOGEN ACTIVATORS IN GASTRIC-CANCER. Oncology Reports, 1, 765-772. https://doi.org/10.3892/or.1.4.765
MLA
YONEMURA, Y., NINOMIYA, I., NOJIMA, N., SUGIYAMA, K., FUJIMURA, T., TSUCHIHARA, K., KAWAMURA, T., KAJI, M., MIYAZAKI, I., ENDO, Y., TANAKA, M., SASAKI, T."PROGNOSTIC VALUE OF UROKINASE-TYPE PLASMINOGEN ACTIVATORS IN GASTRIC-CANCER". Oncology Reports 1.4 (1994): 765-772.
Chicago
YONEMURA, Y., NINOMIYA, I., NOJIMA, N., SUGIYAMA, K., FUJIMURA, T., TSUCHIHARA, K., KAWAMURA, T., KAJI, M., MIYAZAKI, I., ENDO, Y., TANAKA, M., SASAKI, T."PROGNOSTIC VALUE OF UROKINASE-TYPE PLASMINOGEN ACTIVATORS IN GASTRIC-CANCER". Oncology Reports 1, no. 4 (1994): 765-772. https://doi.org/10.3892/or.1.4.765