THE VALUE OF THE LYSOSOMAL PROTEASE CATHEPSIN-D IN EGYPTIAN BLADDER-CANCER
- Authors: S EISSA, O ELAHMADY, AG ELDIN, T HELAL, I KHALAF
Published online on: Friday, July 1, 1994
- Pages: 849-852
- DOI: 10.3892/or.1.4.849
Cathepsin D was measured in cytosols of 60 malignant bladder specimens and normal tissue from the same bladder at safety margin 5 cm of the tumor. Significant elevation in cathepsin D level (50 +/- 3.5 pmol/mg protein) in bladder carcinoma compared to normal tissue (12.7 +/- 1.58 pmol/mg protein) was found. At 100% specificity, cathepsin D sensitivity was 78%. The positivity rate of cathepsin D increased in the presence of lymph node metastasis. The higher concentration of cathepsin D in malignant bladder tissue vs. normal tissue and its correlation with lymph node metastasis could reflect its importance as a marker of metastatic potentiality of primary bladder cancer.