THE VALUE OF THE LYSOSOMAL PROTEASE CATHEPSIN-D IN EGYPTIAN BLADDER-CANCER

  • Authors:
    • S EISSA
    • O ELAHMADY
    • AG ELDIN
    • T HELAL
    • I KHALAF
  • View Affiliations

  • Published online on: July 1, 1994     https://doi.org/10.3892/or.1.4.849
  • Pages: 849-852
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Abstract

Cathepsin D was measured in cytosols of 60 malignant bladder specimens and normal tissue from the same bladder at safety margin 5 cm of the tumor. Significant elevation in cathepsin D level (50 +/- 3.5 pmol/mg protein) in bladder carcinoma compared to normal tissue (12.7 +/- 1.58 pmol/mg protein) was found. At 100% specificity, cathepsin D sensitivity was 78%. The positivity rate of cathepsin D increased in the presence of lymph node metastasis. The higher concentration of cathepsin D in malignant bladder tissue vs. normal tissue and its correlation with lymph node metastasis could reflect its importance as a marker of metastatic potentiality of primary bladder cancer.

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July 1994
Volume 1 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
EISSA S, ELAHMADY O, ELDIN A, HELAL T and KHALAF I: THE VALUE OF THE LYSOSOMAL PROTEASE CATHEPSIN-D IN EGYPTIAN BLADDER-CANCER. Oncol Rep 1: 849-852, 1994
APA
EISSA, S., ELAHMADY, O., ELDIN, A., HELAL, T., & KHALAF, I. (1994). THE VALUE OF THE LYSOSOMAL PROTEASE CATHEPSIN-D IN EGYPTIAN BLADDER-CANCER. Oncology Reports, 1, 849-852. https://doi.org/10.3892/or.1.4.849
MLA
EISSA, S., ELAHMADY, O., ELDIN, A., HELAL, T., KHALAF, I."THE VALUE OF THE LYSOSOMAL PROTEASE CATHEPSIN-D IN EGYPTIAN BLADDER-CANCER". Oncology Reports 1.4 (1994): 849-852.
Chicago
EISSA, S., ELAHMADY, O., ELDIN, A., HELAL, T., KHALAF, I."THE VALUE OF THE LYSOSOMAL PROTEASE CATHEPSIN-D IN EGYPTIAN BLADDER-CANCER". Oncology Reports 1, no. 4 (1994): 849-852. https://doi.org/10.3892/or.1.4.849