THE VALUE OF THE LYSOSOMAL PROTEASE CATHEPSIN-D IN EGYPTIAN BLADDER-CANCER

  • Authors: S EISSA, O ELAHMADY, AG ELDIN, T HELAL, I KHALAF
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  • Published online on: Friday, July 1, 1994
  • Pages: 849-852
  • DOI: 10.3892/or.1.4.849

Abstract

Cathepsin D was measured in cytosols of 60 malignant bladder specimens and normal tissue from the same bladder at safety margin 5 cm of the tumor. Significant elevation in cathepsin D level (50 +/- 3.5 pmol/mg protein) in bladder carcinoma compared to normal tissue (12.7 +/- 1.58 pmol/mg protein) was found. At 100% specificity, cathepsin D sensitivity was 78%. The positivity rate of cathepsin D increased in the presence of lymph node metastasis. The higher concentration of cathepsin D in malignant bladder tissue vs. normal tissue and its correlation with lymph node metastasis could reflect its importance as a marker of metastatic potentiality of primary bladder cancer.
Journal Cover

July 1994
Volume 1 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

2012 Impact Factor: 2.297
Ranked #36/196 Oncology
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APA
EISSA, S., ELAHMADY, O., ELDIN, A., HELAL, T., & KHALAF, I. (1994). THE VALUE OF THE LYSOSOMAL PROTEASE CATHEPSIN-D IN EGYPTIAN BLADDER-CANCER. Oncology Reports, 1(4), 849-852.
MLA
EISSA, ELAHMADY, ELDIN, HELAL, and I KHALAF. "THE VALUE OF THE LYSOSOMAL PROTEASE CATHEPSIN-D IN EGYPTIAN BLADDER-CANCER." Oncology Reports Oncology Reports 1.4 (1994): 849-852.
Chicago
EISSA, ELAHMADY, ELDIN, HELAL, and I KHALAF. "THE VALUE OF THE LYSOSOMAL PROTEASE CATHEPSIN-D IN EGYPTIAN BLADDER-CANCER." Oncology Reports Oncology Reports 1 no. 4 (1994): 849-852.