ONCOGENES AND TUMOR-SUPPRESSOR GENES - 2 DIFFERENT LOOKS OF THE SAME GENE

  • Authors:
    • G CALIN
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  • Published online on: September 1, 1994     https://doi.org/10.3892/or.1.5.987
  • Pages: 987-991
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Abstract

Dominant oncogenes and recessive tumor suppressor genes are widely implicated in the pathogenesis of human neoplasia. Several recent experimental findings suggested that an oncogene and a tumor suppressor gene can share a similar ontogeny from the parental normal 'in vivo' gene. At least three mechanisms have been demonstrated to be responsible for this ambivalent expression: the mutations located in different regions of the gene, transcriptional and post-transcriptional events (especially alternative splicing) and cell- and/or time-dependent control of gene expression. There are also evolutionary explanations for the existence of such genes with ambivalent expression.

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September 1994
Volume 1 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
CALIN G: ONCOGENES AND TUMOR-SUPPRESSOR GENES - 2 DIFFERENT LOOKS OF THE SAME GENE. Oncol Rep 1: 987-991, 1994
APA
CALIN, G. (1994). ONCOGENES AND TUMOR-SUPPRESSOR GENES - 2 DIFFERENT LOOKS OF THE SAME GENE. Oncology Reports, 1, 987-991. https://doi.org/10.3892/or.1.5.987
MLA
CALIN, G."ONCOGENES AND TUMOR-SUPPRESSOR GENES - 2 DIFFERENT LOOKS OF THE SAME GENE". Oncology Reports 1.5 (1994): 987-991.
Chicago
CALIN, G."ONCOGENES AND TUMOR-SUPPRESSOR GENES - 2 DIFFERENT LOOKS OF THE SAME GENE". Oncology Reports 1, no. 5 (1994): 987-991. https://doi.org/10.3892/or.1.5.987