ONCOGENES AND TUMOR-SUPPRESSOR GENES - 2 DIFFERENT LOOKS OF THE SAME GENE
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- Published online on: September 1, 1994 https://doi.org/10.3892/or.1.5.987
- Pages: 987-991
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Abstract
Dominant oncogenes and recessive tumor suppressor genes are widely implicated in the pathogenesis of human neoplasia. Several recent experimental findings suggested that an oncogene and a tumor suppressor gene can share a similar ontogeny from the parental normal 'in vivo' gene. At least three mechanisms have been demonstrated to be responsible for this ambivalent expression: the mutations located in different regions of the gene, transcriptional and post-transcriptional events (especially alternative splicing) and cell- and/or time-dependent control of gene expression. There are also evolutionary explanations for the existence of such genes with ambivalent expression.