MODELING THE DEVELOPMENT OF IN-SITU BREAST-CANCER - A CLONAL EVOLUTIONARY APPROACH

  • Authors: DN POLLER, IO ELLIS
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  • Published online on: Tuesday, November 1, 1994
  • Pages: 1261-1262
  • DOI: 10.3892/or.1.6.1261

Abstract

We present a speculative hypothesis based on the assumption that a morphological parameter of a tumour in this case the nuclear area as assessed by computerised image analysis can be utilised to predict the number of specific events occurring at a gene or chromosomal level within a tumour given the assumption that the tumour morphology is predictive of the clonal evolution of a tumour and clonal progression of neoplasia. Assuming that the phenotype of the tumour is truly determined by the genotype and that morphological variations within a tumour are not due to other factors such analogous to biotypic or ecotypic diversity in animal species we argue that this may be a valuable model to approach the understanding of tumour biology and clonal evolution of tumour cell populations. Such analyses could in future be important in cytogenetic or microdissection studies of DCIS, and could be applicable to studies of clonal evolution in DCIS and other neoplasms using fluorescent in situ hybridisation.
Journal Cover

November 1994
Volume 1 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

2013 Impact Factor: 2.191
Ranked #33/202 Oncology
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APA
POLLER, D., & ELLIS, I. (1994). MODELING THE DEVELOPMENT OF IN-SITU BREAST-CANCER - A CLONAL EVOLUTIONARY APPROACH. Oncology Reports, 1(6), 1261-1262.
MLA
POLLER, and IO ELLIS. "MODELING THE DEVELOPMENT OF IN-SITU BREAST-CANCER - A CLONAL EVOLUTIONARY APPROACH." Oncology Reports Oncology Reports 1.6 (1994): 1261-1262.
Chicago
POLLER, and IO ELLIS. "MODELING THE DEVELOPMENT OF IN-SITU BREAST-CANCER - A CLONAL EVOLUTIONARY APPROACH." Oncology Reports Oncology Reports 1 no. 6 (1994): 1261-1262.