A CLINICAL-STUDY OF IMMUNOTHERAPY VERSUS ENDOCRINE THERAPY VERSUS CHEMOTHERAPY IN THE TREATMENT OF ADVANCED PANCREATIC ADENOCARCINOMA

  • Authors: P LISSONI, A ARDIZZOIA, S MEREGALLI, S BARNI, V FOSSATI, F BRIVIO, G TANCINI
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  • Published online on: Tuesday, November 1, 1994
  • Pages: 1277-1280
  • DOI: 10.3892/or.1.6.1277

Abstract

The advanced carcinoma of pancreas still remains an untreatable disease. Both chemotherapy and hormono-therapy seem not to prolong the survival time. Also immunotherapy with IL-2 has been shown to have no efficacy. Our experimental studies suggested the possibility of enhancing the antitumor activity of IL-2 by the administration of immunomodulating neurohormones, such as melatonin (MLT). This study was carried out to evaluate the efficacy of IL-2 plus MLT in advanced cancer of the pancreas. Fifty patients, with advanced adenocarcinoma of the pancreas, were randomized to receive chemotherapy consisting of 5-FU plus folates, endocrine therapy with LHRH and somatostatin analogues, supportive care alone or immunotherapy with subcutaneous low-dose IL-2 plus MLT. A partial response was obtained in 1/13 patients treated with chemotherapy and in 2/12 patients receiving immunotherapy; no tumor regression was seen in the other groups. The percent of survival at 1 year achieved in patients treated with immunotherapy was significantly higher than in the other groups tested (3/12 vs 1/38; p<0.02). This preliminary study would suggest that the immunotherapy with IL-2 plus MLT may represent a new promising treatment of advanced pancreatic adenocarcinoma.
Journal Cover

November 1994
Volume 1 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

2012 Impact Factor: 2.297
Ranked #36/196 Oncology
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APA
LISSONI, P., ARDIZZOIA, A., MEREGALLI, S., BARNI, S., FOSSATI, V., BRIVIO, F., & TANCINI, G. (1994). A CLINICAL-STUDY OF IMMUNOTHERAPY VERSUS ENDOCRINE THERAPY VERSUS CHEMOTHERAPY IN THE TREATMENT OF ADVANCED PANCREATIC ADENOCARCINOMA. Oncology Reports, 1(6), 1277-1280.
MLA
LISSONI, ARDIZZOIA, MEREGALLI, BARNI, FOSSATI, BRIVIO, and G TANCINI. "A CLINICAL-STUDY OF IMMUNOTHERAPY VERSUS ENDOCRINE THERAPY VERSUS CHEMOTHERAPY IN THE TREATMENT OF ADVANCED PANCREATIC ADENOCARCINOMA." Oncology Reports Oncology Reports 1.6 (1994): 1277-1280.
Chicago
LISSONI, ARDIZZOIA, MEREGALLI, BARNI, FOSSATI, BRIVIO, and G TANCINI. "A CLINICAL-STUDY OF IMMUNOTHERAPY VERSUS ENDOCRINE THERAPY VERSUS CHEMOTHERAPY IN THE TREATMENT OF ADVANCED PANCREATIC ADENOCARCINOMA." Oncology Reports Oncology Reports 1 no. 6 (1994): 1277-1280.