CD40 expression in prostate cancer: A potential diagnostic and therapeutic molecule

  • Authors:
    • D. H. Palmer
    • S. A. Hussain
    • R. Ganesan
    • P. W. Cooke
    • D. M.A. Wallace
    • L. S. Young
    • N. D. James
  • View Affiliations

  • Published online on: October 1, 2004     https://doi.org/10.3892/or.12.4.679
  • Pages: 679-682
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Abstract

CD40, a member of the TNF receptor superfamily, is widely expressed on human immune cells. It is also frequently expressed on epithelial malignancies, suggesting that CD40 may contribute to the pathogenesis of some cancers. Activation of CD40 in cancer cells induces growth inhibition and sensitization to apoptotic stimuli. This study investigates CD40 expression in archival tissue from patients with prostate cancer. In all cases, normal prostatic acini expressed CD40, however, in 56 of 57 cases of prostate cancer no CD40 expression was detected. In the one other case, patchy CD40 expression was associated with prostatic in situ neoplasia. In conclusion, invasive prostate cancer is a CD40-negative tumour. These data may be relevant as a diagnostic tool; in providing insight into progression of cancer from normal epithelium; and in identifying novel therapeutic strategies for prostate cancer.

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October 2004
Volume 12 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Palmer DH, Hussain SA, Ganesan R, Cooke PW, Wallace DM, Young LS and James ND: CD40 expression in prostate cancer: A potential diagnostic and therapeutic molecule. Oncol Rep 12: 679-682, 2004
APA
Palmer, D.H., Hussain, S.A., Ganesan, R., Cooke, P.W., Wallace, D.M., Young, L.S., & James, N.D. (2004). CD40 expression in prostate cancer: A potential diagnostic and therapeutic molecule. Oncology Reports, 12, 679-682. https://doi.org/10.3892/or.12.4.679
MLA
Palmer, D. H., Hussain, S. A., Ganesan, R., Cooke, P. W., Wallace, D. M., Young, L. S., James, N. D."CD40 expression in prostate cancer: A potential diagnostic and therapeutic molecule". Oncology Reports 12.4 (2004): 679-682.
Chicago
Palmer, D. H., Hussain, S. A., Ganesan, R., Cooke, P. W., Wallace, D. M., Young, L. S., James, N. D."CD40 expression in prostate cancer: A potential diagnostic and therapeutic molecule". Oncology Reports 12, no. 4 (2004): 679-682. https://doi.org/10.3892/or.12.4.679