Hepatocyte growth factor and c-Met immunoreactivity are associated with metastasis in high grade salivary gland carcinoma

  • Authors:
    • Keiichi Tsukinoki
    • Masanori Yasuda
    • Yusuke Mori
    • Shigeyuki Asano
    • Hiroyuki Naito
    • Yoshihide Ota
    • R. Yoshiyuki Osamura
    • Yoshihisa Watanabe
  • View Affiliations

  • Published online on: November 1, 2004     https://doi.org/10.3892/or.12.5.1017
  • Pages: 1017-1021
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Abstract

Interactions between hepatocyte growth factor (HGF) and its receptor, c-Met, have been associated with invasion, metastasis and carcinogenesis in in vitro experiments. We investigated the relationship between HGF/c-Met immunoreactivity and the clinical features of 33 patients with high grade salivary gland carcinomas. c-Met and stromal HGF (expression of HGF in fibroblasts adjacent to tumor nests) were found to significantly correlate with regional lymph node and distant metastasis (p<0.05), but not with HGF expression, in tumor cells. Stromal HGF was also found to correlate with tumor size (p<0.05). In addition, a significant correlation between c-Met and stromal HGF expression (p<0.0001) was observed. Overall survival in patients with c-Met and stromal HGF immunoreactivity was significantly worse than in patients without c-Met and stromal HGF immunoreactivity (p=0.0002). The present findings suggest that HGF may bind to c-Met in a paracrine fashion, thereby enabling metastasis of high grade salivary gland carcinomas. Thus, HGF/c-Met immunoreactivity might be associated with a poor prognosis in patients with high grade salivary gland carcinomas.

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November 2004
Volume 12 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Tsukinoki K, Yasuda M, Mori Y, Asano S, Naito H, Ota Y, Osamura RY and Watanabe Y: Hepatocyte growth factor and c-Met immunoreactivity are associated with metastasis in high grade salivary gland carcinoma. Oncol Rep 12: 1017-1021, 2004
APA
Tsukinoki, K., Yasuda, M., Mori, Y., Asano, S., Naito, H., Ota, Y. ... Watanabe, Y. (2004). Hepatocyte growth factor and c-Met immunoreactivity are associated with metastasis in high grade salivary gland carcinoma. Oncology Reports, 12, 1017-1021. https://doi.org/10.3892/or.12.5.1017
MLA
Tsukinoki, K., Yasuda, M., Mori, Y., Asano, S., Naito, H., Ota, Y., Osamura, R. Y., Watanabe, Y."Hepatocyte growth factor and c-Met immunoreactivity are associated with metastasis in high grade salivary gland carcinoma". Oncology Reports 12.5 (2004): 1017-1021.
Chicago
Tsukinoki, K., Yasuda, M., Mori, Y., Asano, S., Naito, H., Ota, Y., Osamura, R. Y., Watanabe, Y."Hepatocyte growth factor and c-Met immunoreactivity are associated with metastasis in high grade salivary gland carcinoma". Oncology Reports 12, no. 5 (2004): 1017-1021. https://doi.org/10.3892/or.12.5.1017