Nicotine induces chromatin changes and c-Jun up-regulation in HL-60 leukemia cells

  • Authors: Emilie Landais, Victoria El-Khoury, Alain Prevost, Jean Dufer, Françoise Liautaud-Roger
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  • Published online on: Thursday, December 1, 2005
  • Pages: 1553-1558
  • DOI: 10.3892/or.14.6.1553

Abstract

Although nicotine has been implicated as a potential factor in the pathogenesis of human cancer, its mechanisms of action regarding cancer development remain largely unknown. HL-60 cells were used to investigate the effects of a short-term treatment with nicotine at concentrations found in the blood of smokers. The findings show that nicotine induces chromatin decondensation, histone H3 acetylation and up-regulation of the c-Jun transcription factor mRNA. This increase is inhibited by mecamylamine, a nicotinic receptor antagonist, suggesting that nicotine alters cellular function directly via nicotinic acetylcholine receptors and may then play a role in cell physiology and tumor promotion.
Journal Cover

December 2005
Volume 14 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

2012 Impact Factor: 2.191
Ranked #33/202 Oncology
(total number of cites)

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APA
Landais, E., El-Khoury, V., Prevost, A., Dufer, J., & Liautaud-Roger, F. (2005). Nicotine induces chromatin changes and c-Jun up-regulation in HL-60 leukemia cells. Oncology Reports, 14(6), 1553-1558.
MLA
Landais, El-Khoury, Prevost, Dufer, and Françoise Liautaud-Roger. "Nicotine induces chromatin changes and c-Jun up-regulation in HL-60 leukemia cells." Oncology Reports Oncology Reports 14.6 (2005): 1553-1558.
Chicago
Landais, El-Khoury, Prevost, Dufer, and Françoise Liautaud-Roger. "Nicotine induces chromatin changes and c-Jun up-regulation in HL-60 leukemia cells." Oncology Reports Oncology Reports 14 no. 6 (2005): 1553-1558.