Aberrant promoter methylation of EDNRB in lung cancer in Taiwan

  • Authors:
    • Shu-Chen Chen
    • Chia-Yu Lin
    • Ya-Hui Chen
    • Hsin-Yuan Fang
    • Ching-Yuan Cheng
    • Chih-Wen Chang
    • Ruei-A Chen
    • Hui-Lung Tai
    • Chien-Hsing Lee
    • Ming-Chih Chou
    • Torng-Sen Lin
    • Li-Sung Hsu
  • View Affiliations

  • Published online on: January 1, 2006     https://doi.org/10.3892/or.15.1.167
  • Pages: 167-172
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Abstract

Hypermethylation has been shown in the promoter region of the endothelin receptor B (EDNRB) gene in several human tumors, but its role in lung cancer formation is unclear. In this study, genomic DNA from lung cancer patients was subjected to methylation-specific PCR to determine the methylation status of the EDNRB gene in lung cancer. Aberrant methylation of the EDNRB gene was detected in 32.9% (26 of 79) lung cancer patients. Promoter hypermethylation of EDNRB was found to significantly differ with histological type but was not correlated to other clinicopathological characteristics. Decreased mRNA transcripts were correlated to aberrant methylation. Treatment with 5-aza-deoxycytidine reversed the methylation status and re-expression of the EDNRB gene in the H1355 human lung cancer cell line. Our results suggest that inactivation of the EDNRB gene through epigenetic alteration is highly prevalent in lung cancer in Taiwan.

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January 2006
Volume 15 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Chen S, Lin C, Chen Y, Fang H, Cheng C, Chang C, Chen R, Tai H, Lee C, Chou M, Chou M, et al: Aberrant promoter methylation of EDNRB in lung cancer in Taiwan. Oncol Rep 15: 167-172, 2006
APA
Chen, S., Lin, C., Chen, Y., Fang, H., Cheng, C., Chang, C. ... Hsu, L. (2006). Aberrant promoter methylation of EDNRB in lung cancer in Taiwan. Oncology Reports, 15, 167-172. https://doi.org/10.3892/or.15.1.167
MLA
Chen, S., Lin, C., Chen, Y., Fang, H., Cheng, C., Chang, C., Chen, R., Tai, H., Lee, C., Chou, M., Lin, T., Hsu, L."Aberrant promoter methylation of EDNRB in lung cancer in Taiwan". Oncology Reports 15.1 (2006): 167-172.
Chicago
Chen, S., Lin, C., Chen, Y., Fang, H., Cheng, C., Chang, C., Chen, R., Tai, H., Lee, C., Chou, M., Lin, T., Hsu, L."Aberrant promoter methylation of EDNRB in lung cancer in Taiwan". Oncology Reports 15, no. 1 (2006): 167-172. https://doi.org/10.3892/or.15.1.167