Relationship of aberrant DNA hypermethylation of CHFR with sensitivity to taxanes in endometrial cancer

  • Authors:
    • Megumi Yanokura
    • Kouji Banno
    • Makiko Kawaguchi
    • Nobumaru Hirao
    • Akira Hirasawa
    • Nobuyuki Susumu
    • Katsumi Tsukazaki
    • Daisuke Aoki
  • View Affiliations

  • Published online on: January 1, 2007     https://doi.org/10.3892/or.17.1.41
  • Pages: 41-48
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Abstract

The relationship of aberrant DNA hypermethylation of cell cycle checkpoint genes with the sensitivity of cancer cells to anticancer drugs is a question of current interest. In this study, we investigated the relationship between aberrant hypermethylation of the CHFR (checkpoint with forkhead-associated and ring finger) mitotic checkpoint gene and sensitivity to taxanes in endometrial cancer. Methylation-specific PCR (MSP) indicated aberrant hypermethylation of CHFR in 12.0% (6/50) of endometrial cancer specimens, and suggested that aberrant hypermethylation is significantly more frequent in poorly differentiated adenocarcinoma (G3) (p<0.05). Of six culture cell lines, SNG-II and HEC108 cells showed aberrant hypermethylation and reduced expression of CHFR. These cells had high sensitivity to taxanes but became resistant after demethylation. Cancer specimens with aberrant hypermethylation of CHFR also exhibited high sensitivity to taxanes. To our knowledge, this study is the first to examine aberrant hypermethylation of CHFR in endometrial cancer, and our results suggest that the methylation status of CHFR may be a new molecular index that will allow design of personalized treatment in endometrial cancer. This may be particularly important in poorly differentiated adenocarcinoma (G3), which is known to have a poor prognosis.

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January 2007
Volume 17 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Yanokura M, Banno K, Kawaguchi M, Hirao N, Hirasawa A, Susumu N, Tsukazaki K and Aoki D: Relationship of aberrant DNA hypermethylation of CHFR with sensitivity to taxanes in endometrial cancer. Oncol Rep 17: 41-48, 2007
APA
Yanokura, M., Banno, K., Kawaguchi, M., Hirao, N., Hirasawa, A., Susumu, N. ... Aoki, D. (2007). Relationship of aberrant DNA hypermethylation of CHFR with sensitivity to taxanes in endometrial cancer. Oncology Reports, 17, 41-48. https://doi.org/10.3892/or.17.1.41
MLA
Yanokura, M., Banno, K., Kawaguchi, M., Hirao, N., Hirasawa, A., Susumu, N., Tsukazaki, K., Aoki, D."Relationship of aberrant DNA hypermethylation of CHFR with sensitivity to taxanes in endometrial cancer". Oncology Reports 17.1 (2007): 41-48.
Chicago
Yanokura, M., Banno, K., Kawaguchi, M., Hirao, N., Hirasawa, A., Susumu, N., Tsukazaki, K., Aoki, D."Relationship of aberrant DNA hypermethylation of CHFR with sensitivity to taxanes in endometrial cancer". Oncology Reports 17, no. 1 (2007): 41-48. https://doi.org/10.3892/or.17.1.41