Induction of α2-antiplasmin inhibits E-cadherin processing mediated by the plasminogen activator/plasmin system, leading to suppression of progression of oral squamous cell carcinoma via upregulation of cell-cell adhesion

  • Authors:
    • Yasutaka Hayashido
    • Tomoaki Hamana
    • Yasutaka Ishida
    • Tomoaki Shintani
    • Koh-ichi Koizumi
    • Tetsuji Okamoto
  • View Affiliations

  • Published online on: February 1, 2007     https://doi.org/10.3892/or.17.2.417
  • Pages: 417-423
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Abstract

The plasminogen activator/plasmin system is one of the main protease systems involved in tumor cell invasion and metastasis. Our previous study has shown that plasmin degrades E-cadherin and promotes cell dissemination by downregulation of E-cadherin-mediated cell-cell adhesion in oral squamous cell carcinoma (SCC) cells. To examine the effect of downregulation of the plasminogen activator/plasmin system by α2-antiplasmin (α2-AP) on cell-cell adhesion mediated by E-cadherin in oral SCC cells, the oral SCC cell line SCCKN was stably transfected with α2-AP cDNA. Induction of α2-AP expression led to the inhibition of the proteolysis of E-cadherin by plasminogen activator/plasmin in SCC cells, resulting in the enhancement of the cell aggregation and the suppression of the cell motility. Moreover, α2-AP also reduced the ability of SCC cells to invade type I collagen gel, and suppressed tumorigenicity in vivo. These results suggested that downregulation of the plasminogen activator/ plasmin system by α2-AP might be a potent therapeutic approach to prevent the progression of oral SCC.

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February 2007
Volume 17 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Hayashido Y, Hamana T, Ishida Y, Shintani T, Koizumi K and Okamoto T: Induction of α2-antiplasmin inhibits E-cadherin processing mediated by the plasminogen activator/plasmin system, leading to suppression of progression of oral squamous cell carcinoma via upregulation of cell-cell adhesion. Oncol Rep 17: 417-423, 2007
APA
Hayashido, Y., Hamana, T., Ishida, Y., Shintani, T., Koizumi, K., & Okamoto, T. (2007). Induction of α2-antiplasmin inhibits E-cadherin processing mediated by the plasminogen activator/plasmin system, leading to suppression of progression of oral squamous cell carcinoma via upregulation of cell-cell adhesion. Oncology Reports, 17, 417-423. https://doi.org/10.3892/or.17.2.417
MLA
Hayashido, Y., Hamana, T., Ishida, Y., Shintani, T., Koizumi, K., Okamoto, T."Induction of α2-antiplasmin inhibits E-cadherin processing mediated by the plasminogen activator/plasmin system, leading to suppression of progression of oral squamous cell carcinoma via upregulation of cell-cell adhesion". Oncology Reports 17.2 (2007): 417-423.
Chicago
Hayashido, Y., Hamana, T., Ishida, Y., Shintani, T., Koizumi, K., Okamoto, T."Induction of α2-antiplasmin inhibits E-cadherin processing mediated by the plasminogen activator/plasmin system, leading to suppression of progression of oral squamous cell carcinoma via upregulation of cell-cell adhesion". Oncology Reports 17, no. 2 (2007): 417-423. https://doi.org/10.3892/or.17.2.417