Notch signaling inhibits growth of the human lung adenocarcinoma cell line A549

  • Authors:
    • Qijun Zheng
    • Hongyan Qin
    • Hongwei Zhang
    • Junchang Li
    • Lihong Hou
    • Hongbin Wang
    • Xueping Zhang
    • Suzhen Zhang
    • Lei Feng
    • Yingmin Liang
    • Hua Han
    • Dinghua Yi
  • View Affiliations

  • Published online on: April 1, 2007     https://doi.org/10.3892/or.17.4.847
  • Pages: 847-852
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Abstract

In lung cancers the Notch signaling may function as an oncogene or a tumor suppressor depending on the tumor cell types. In this study we examined the expression of Notch receptors in the human lung adenocarcinoma cell lines A549 and SPC-A-1. We over-expressed the active form of Notch1 (NIC) in A549 cells by constitutive transfection to evaluate the effects of the Notch signaling on lung adenocarcinoma cells. Our results showed that over-expression of NIC in A549 cells inhibited the growth of A549 cells through induction of cell cycle arrest. Moreover, over-expression of NIC inhibited the colony-forming activity of A549 cells when cultured in methylcellulose medium, and their ability to form tumors in nude mice. These data suggest that the Notch signaling may function as a tumor inhibitor in human lung adenocarcinoma cells.

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April 2007
Volume 17 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Zheng Q, Qin H, Zhang H, Li J, Hou L, Wang H, Zhang X, Zhang S, Feng L, Liang Y, Liang Y, et al: Notch signaling inhibits growth of the human lung adenocarcinoma cell line A549. Oncol Rep 17: 847-852, 2007
APA
Zheng, Q., Qin, H., Zhang, H., Li, J., Hou, L., Wang, H. ... Yi, D. (2007). Notch signaling inhibits growth of the human lung adenocarcinoma cell line A549. Oncology Reports, 17, 847-852. https://doi.org/10.3892/or.17.4.847
MLA
Zheng, Q., Qin, H., Zhang, H., Li, J., Hou, L., Wang, H., Zhang, X., Zhang, S., Feng, L., Liang, Y., Han, H., Yi, D."Notch signaling inhibits growth of the human lung adenocarcinoma cell line A549". Oncology Reports 17.4 (2007): 847-852.
Chicago
Zheng, Q., Qin, H., Zhang, H., Li, J., Hou, L., Wang, H., Zhang, X., Zhang, S., Feng, L., Liang, Y., Han, H., Yi, D."Notch signaling inhibits growth of the human lung adenocarcinoma cell line A549". Oncology Reports 17, no. 4 (2007): 847-852. https://doi.org/10.3892/or.17.4.847