Effect of cranberry juice concentrate on chemically-induced urinary bladder cancers

  • Authors: Jeevan K. Prasain, Kenneth Jones, Ray Moore, Stephen Barnes, Marge Leahy, Robin Roderick, M. Margaret Juliana, Clinton J. Grubbs
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  • Published online on: Sunday, June 1, 2008
  • Pages: 1565-1570
  • DOI: 10.3892/or.19.6.1565

Abstract

The chemopreventive efficacy of cranberry juice concentrate in an experimental model of urinary bladder cancer was evaluated using female Fischer-344 rats. The animals received N-butyl-N-(4-hydroxybutyl)-nitrosamine (OH-BBN) for a period of eight weeks. Cranberry juice concentrate was administered at doses of 1.0 or 0.5 ml/rat/day beginning one week after the final OH-BBN treatment and continuing until the end of the study. The urinary bladders of all the rats were weighed and examined grossly for lesions, and all masses were submitted for pathological evaluation. A dose-dependent preventive effect of cranberry treatment was observed, with a reduced number of urinary bladder cancers (38%) in the 1.0 ml/rat/day group versus the control group. The cranberry extract neither affected body weight gain nor caused other signs of toxicity. For the metabolic studies, serum and urine were collected at 4 and 12 h after the administration of the cranberry juice concentrate and were analyzed by LC-MS/MS. Quercetin and its methylated derivative were detected in the urine samples. However, no quercetin was detected in the serum samples, indicating its poor bioavailability. These data suggest that components of cranberries may be effective in preventing urinary bladder carcinogenesis.
Journal Cover

June 2008
Volume 19 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

2013 Impact Factor: 2.191
Ranked #33/202 Oncology
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APA
Prasain, J., Jones, K., Moore, R., Barnes, S., Leahy, M., Roderick, R., Juliana, M., & Grubbs, C. (2008). Effect of cranberry juice concentrate on chemically-induced urinary bladder cancers. Oncology Reports, 19(6), 1565-1570.
MLA
Prasain, Jones, Moore, Barnes, Leahy, Roderick, Juliana, and Clinton Grubbs. "Effect of cranberry juice concentrate on chemically-induced urinary bladder cancers." Oncology Reports Oncology Reports 19.6 (2008): 1565-1570.
Chicago
Prasain, Jones, Moore, Barnes, Leahy, Roderick, Juliana, and Clinton Grubbs. "Effect of cranberry juice concentrate on chemically-induced urinary bladder cancers." Oncology Reports Oncology Reports 19 no. 6 (2008): 1565-1570.