THE CONDITIONING EFFECT OF RK-28 IN A COMBINED TREATMENT WITH IRRADIATION AGAINST V-79 CELLS

  • Authors:
    • H MATSUOKA
    • Y SEO
    • K HATA
    • S WADA
    • T SAITO
    • H TOMODA
    • M FURUSAWA
  • View Affiliations

  • Published online on: September 1, 1995     https://doi.org/10.3892/or.2.5.777
  • Pages: 777-779
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Abstract

The conditioning effect of RK-28, one of the nitroimidazole nucleoside analogues, in a combined treatment with irradiation against aerobic V-79 cells in an exponentially-growing phase was investigated. The growth rate of the V-79 cells in 5% DMEM was not different from that in the medium containing 0.2 mM RK-28. The growth of V-79 cells treated with 6 Gy-irradiation in the medium containing 0.2 mM RK-28 showed a statistically more significant inhibition than that with a single modality treatment of irradiation. The number (3.3x10(3) cells/dish at 24 h after irradiation) of cells incubated for 24 straight hours in the medium containing RK-28 was significantly lower than that (9.5x10(3) cells/dish at 24 h after irradiation) of the cells which were placed into a fresh medium immediately after irradiation. Moreover, the number of the cells, in which the medium was changed to a conditioned medium containing 0.2 mM RK-28 immediately after irradiation with the same dose of RK-28, was 2.1x10(3) cells/dish at 24 h after irradiation, and thereafter did not increase. These results indicated that RK-28 induced growth inhibition factors from exponentially-growing V-79 cells in an aerobic state, due to the combined treatment with irradiation.

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September 1995
Volume 2 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
MATSUOKA H, SEO Y, HATA K, WADA S, SAITO T, TOMODA H and FURUSAWA M: THE CONDITIONING EFFECT OF RK-28 IN A COMBINED TREATMENT WITH IRRADIATION AGAINST V-79 CELLS. Oncol Rep 2: 777-779, 1995
APA
MATSUOKA, H., SEO, Y., HATA, K., WADA, S., SAITO, T., TOMODA, H., & FURUSAWA, M. (1995). THE CONDITIONING EFFECT OF RK-28 IN A COMBINED TREATMENT WITH IRRADIATION AGAINST V-79 CELLS. Oncology Reports, 2, 777-779. https://doi.org/10.3892/or.2.5.777
MLA
MATSUOKA, H., SEO, Y., HATA, K., WADA, S., SAITO, T., TOMODA, H., FURUSAWA, M."THE CONDITIONING EFFECT OF RK-28 IN A COMBINED TREATMENT WITH IRRADIATION AGAINST V-79 CELLS". Oncology Reports 2.5 (1995): 777-779.
Chicago
MATSUOKA, H., SEO, Y., HATA, K., WADA, S., SAITO, T., TOMODA, H., FURUSAWA, M."THE CONDITIONING EFFECT OF RK-28 IN A COMBINED TREATMENT WITH IRRADIATION AGAINST V-79 CELLS". Oncology Reports 2, no. 5 (1995): 777-779. https://doi.org/10.3892/or.2.5.777