THE CONDITIONING EFFECT OF RK-28 IN A COMBINED TREATMENT WITH IRRADIATION AGAINST V-79 CELLS

  • Authors: H MATSUOKA, Y SEO, K HATA, S WADA, T SAITO, H TOMODA, M FURUSAWA
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  • Published online on: Friday, September 1, 1995
  • Pages: 777-779
  • DOI: 10.3892/or.2.5.777

Abstract

The conditioning effect of RK-28, one of the nitroimidazole nucleoside analogues, in a combined treatment with irradiation against aerobic V-79 cells in an exponentially-growing phase was investigated. The growth rate of the V-79 cells in 5% DMEM was not different from that in the medium containing 0.2 mM RK-28. The growth of V-79 cells treated with 6 Gy-irradiation in the medium containing 0.2 mM RK-28 showed a statistically more significant inhibition than that with a single modality treatment of irradiation. The number (3.3x10(3) cells/dish at 24 h after irradiation) of cells incubated for 24 straight hours in the medium containing RK-28 was significantly lower than that (9.5x10(3) cells/dish at 24 h after irradiation) of the cells which were placed into a fresh medium immediately after irradiation. Moreover, the number of the cells, in which the medium was changed to a conditioned medium containing 0.2 mM RK-28 immediately after irradiation with the same dose of RK-28, was 2.1x10(3) cells/dish at 24 h after irradiation, and thereafter did not increase. These results indicated that RK-28 induced growth inhibition factors from exponentially-growing V-79 cells in an aerobic state, due to the combined treatment with irradiation.
Journal Cover

September 1995
Volume 2 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

2012 Impact Factor: 2.297
Ranked #36/196 Oncology
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APA
MATSUOKA, H., SEO, Y., HATA, K., WADA, S., SAITO, T., TOMODA, H., & FURUSAWA, M. (1995). THE CONDITIONING EFFECT OF RK-28 IN A COMBINED TREATMENT WITH IRRADIATION AGAINST V-79 CELLS. Oncology Reports, 2(5), 777-779.
MLA
MATSUOKA, SEO, HATA, WADA, SAITO, TOMODA, and M FURUSAWA. "THE CONDITIONING EFFECT OF RK-28 IN A COMBINED TREATMENT WITH IRRADIATION AGAINST V-79 CELLS." Oncology Reports Oncology Reports 2.5 (1995): 777-779.
Chicago
MATSUOKA, SEO, HATA, WADA, SAITO, TOMODA, and M FURUSAWA. "THE CONDITIONING EFFECT OF RK-28 IN A COMBINED TREATMENT WITH IRRADIATION AGAINST V-79 CELLS." Oncology Reports Oncology Reports 2 no. 5 (1995): 777-779.