Activation of Akt-mTOR-p70S6K pathway in angiogenesis in hepatocellular carcinoma

  • Authors:
    • Wei Li
    • Dongfeng Tan
    • Zhaoping Zhang
    • John J. Liang
    • Robert E. Brown
  • Corresponding author:
  • View Affiliations

  • Published online on: Wednesday, October 1, 2008
  • Pages: 713-719
  • DOI: 10.3892/or_00000064

Abstract

Angiogenesis is an essential process for progression of hepatocellular carcinoma (HCC). The Akt-mTOR-p70S6K signal pathway has been recognized for its roles in regulating neoangiogenesis. The role of activation of the pathway in HCC progression is poorly understood. This study aimed to evaluate the immunohistochemical expression of the phosphorylated forms of the three key constituent proteins (Akt, mTOR and p70S6K) of the Akt-mTOR-p70S6K signal pathway in HCC and non-HCC tissue. Formalin-fixed paraffin-embedded tissue sections of 51 HCC, 9 hepatocellular adenoma (HCA), 48 cirrhotic nodules (CN) and 17 normal liver tissues (NLT) were immunostained for p-Akt, p-mTOR and p-p70S6K. The number of p-Akt and p-p70S6K-positive sinusoidal endothelial cells (SEC) and the intensity of immunostaining were significantly increased in HCC compared with HA, CN and NLT (p<0.01). p-mTOR in SEC tended to have an increased expression in SEC in HCC versus non-HCC tissue (p>0.05). There was a significant correlation between a high p-Akt and p-p70S6K expression, and a venous and capsular invasion of HCC. Our results suggest that activation of the Akt-mTOR-p70S6K pathway plays a significant role in HCC progression by promoting neoangiogenesis. Molecular strategies aimed at inhibiting this signal pathway may be of therapeutic use for the treatment of HCC.
Journal Cover

October 2008
Volume 20 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

2013 Impact Factor: 2.191
Ranked #33/202 Oncology
(total number of cites)

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APA
Li, W., Tan, D., Zhang, Z., Liang, J.J., & Brown, R.E. (2008). Activation of Akt-mTOR-p70S6K pathway in angiogenesis in hepatocellular carcinoma. Oncology Reports, 20, 713-719. http://dx.doi.org/10.3892/or_00000064
MLA
Li, W., Tan, D., Zhang, Z., Liang, J. J., Brown, R. E."Activation of Akt-mTOR-p70S6K pathway in angiogenesis in hepatocellular carcinoma". Oncology Reports 20.4 (2008): 713-719.
Chicago
Li, W., Tan, D., Zhang, Z., Liang, J. J., Brown, R. E."Activation of Akt-mTOR-p70S6K pathway in angiogenesis in hepatocellular carcinoma". Oncology Reports 20, no. 4 (2008): 713-719. http://dx.doi.org/10.3892/or_00000064