Hyperbaric oxygen as a chemotherapy adjuvant in the treatment of osteosarcoma

  • Authors:
    • Yasuomi Kawasoe
    • Masahiro Yokouchi
    • Yoshinori Ueno
    • Hiroaki Iwaya
    • Hiroki Yoshida
    • Setsuro Komiya
  • View Affiliations

  • Published online on: November 1, 2009     https://doi.org/10.3892/or_00000534
  • Pages: 1045-1050
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Abstract

Although hyperbaric oxygen has been shown to enhance the efficacy of radiotherapy and chemotherapy for the treatment of several malignant tumors, the impact of hyperbaric oxygen on osteosarcoma has not yet been demonstrated. In this study, we investigated the efficacy of hyperbaric oxygen alone and in combination with an anti-cancer drug as an adjuvant to chemotherapy. In vitro, highly metastatic murine osteosarcoma cell lines were exposed to hyperbaric oxygen and cell viability was examined. Hyperbaric oxygen alone significantly suppressed cell proliferation, and hyperbaric oxygen plus carboplatin exhibited significant synergism in suppression of cell proliferation. In vivo, C3H mice were subcutaneously inoculated with osteosarcoma cells and divided into four groups: control, hyperbaric oxygen, carboplatin, and carboplatin plus hyperbaric oxygen. After 5 weeks, increase in both tumor volume and number of lung metastases was significantly suppressed in the hyperbaric oxygen group. Concomitant hyperbaric oxygen clearly enhanced the chemotherapeutic effects of carboplatin on both tumor growth and lung metastasis in osteosarcoma-bearing mice. Moreover, mortality in the carboplatin plus hyperbaric oxygen group was significantly lower than in the other three groups. These findings suggest that hyperbaric oxygen plus carboplatin combination therapy could be an appropriate therapeutic regimen for the treatment of patients with osteosarcoma.

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November 2009
Volume 22 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Kawasoe Y, Yokouchi M, Ueno Y, Iwaya H, Yoshida H and Komiya S: Hyperbaric oxygen as a chemotherapy adjuvant in the treatment of osteosarcoma. Oncol Rep 22: 1045-1050, 2009
APA
Kawasoe, Y., Yokouchi, M., Ueno, Y., Iwaya, H., Yoshida, H., & Komiya, S. (2009). Hyperbaric oxygen as a chemotherapy adjuvant in the treatment of osteosarcoma. Oncology Reports, 22, 1045-1050. https://doi.org/10.3892/or_00000534
MLA
Kawasoe, Y., Yokouchi, M., Ueno, Y., Iwaya, H., Yoshida, H., Komiya, S."Hyperbaric oxygen as a chemotherapy adjuvant in the treatment of osteosarcoma". Oncology Reports 22.5 (2009): 1045-1050.
Chicago
Kawasoe, Y., Yokouchi, M., Ueno, Y., Iwaya, H., Yoshida, H., Komiya, S."Hyperbaric oxygen as a chemotherapy adjuvant in the treatment of osteosarcoma". Oncology Reports 22, no. 5 (2009): 1045-1050. https://doi.org/10.3892/or_00000534