Mitochondrial NADH-dehydrogenase polymorphisms as sporadic breast cancer risk factor

  • Authors:
    • Anna M. Czarnecka
    • Aleksandra Klemba
    • Tomasz Krawczyk
    • Marek Zdrozny
    • Rebecca S. Arnold
    • Ewa Bartnik
    • John A. Petros
  • View Affiliations

  • Published online on: February 1, 2010     https://doi.org/10.3892/or_00000666
  • Pages: 531-535
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Abstract

Breast cancer is the most frequently diagnosed female cancer all over the world. Although the molecular genetics of this disease has been the focus of many projects for over 20 years, the number of prognostic markers used in clinics is still unsatisfactory. Mitochondrial DNA mutations have been reported in many breast cancer studies. To investigate the possible role of mitochondrial inherited polymorphisms in breast cancer development we analyzed the sequence of NADH-dehydrogenase genes in cancer samples and their corresponding normal tissues. We detected increased incidence of mtDNA polymorphisms, in particular very rare polymorphisms such as A4727G, G9947A, A10044G, A10283G, T11233C, and C11503T. Our report supports the notion that mtDNA polymorphisms establish a specific genetic background for breast cancer development and that mtDNA analysis may help in selection of cohorts that should undergo intensive screening and early detection programs.

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February 2010
Volume 23 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Czarnecka AM, Klemba A, Krawczyk T, Zdrozny M, Arnold RS, Bartnik E and Petros JA: Mitochondrial NADH-dehydrogenase polymorphisms as sporadic breast cancer risk factor. Oncol Rep 23: 531-535, 2010
APA
Czarnecka, A.M., Klemba, A., Krawczyk, T., Zdrozny, M., Arnold, R.S., Bartnik, E., & Petros, J.A. (2010). Mitochondrial NADH-dehydrogenase polymorphisms as sporadic breast cancer risk factor. Oncology Reports, 23, 531-535. https://doi.org/10.3892/or_00000666
MLA
Czarnecka, A. M., Klemba, A., Krawczyk, T., Zdrozny, M., Arnold, R. S., Bartnik, E., Petros, J. A."Mitochondrial NADH-dehydrogenase polymorphisms as sporadic breast cancer risk factor". Oncology Reports 23.2 (2010): 531-535.
Chicago
Czarnecka, A. M., Klemba, A., Krawczyk, T., Zdrozny, M., Arnold, R. S., Bartnik, E., Petros, J. A."Mitochondrial NADH-dehydrogenase polymorphisms as sporadic breast cancer risk factor". Oncology Reports 23, no. 2 (2010): 531-535. https://doi.org/10.3892/or_00000666