Open Access

Hyperthermic isolated limb perfusion for recurrent melanomas and soft tissue sarcomas: Feasibility and reproducibility in a multi-institutional Hellenic collaborative study

  • Authors: Konstantinos Lasithiotakis, George Economou, Helen Gogas, Christos Ioannou, Konstantinos Perisynakis, Dimitrios Filis, Ourania Kastana, Dimitrios Bafaloukos, Marios Decatris, Nikolaos Catodritis, Konstantina Frangia, George Papadakis, Michael Magarakis, Dimosthenis Tsoutsos, Emmanuel Chrysos, George Chalkiadakis, Odysseas Zoras
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  • Published online on: Thursday, April 1, 2010
  • Pages: 1077-1083
  • DOI: 10.3892/or_00000735

Abstract

Hyperthermic isolated limb perfusion with TNF-α and melphalan (TM-HILP) is a complicated surgical procedure. Herein, we present the experience of the Hellenic collaborating centers with TM-HILP for inoperable in-transit melanoma and soft tissue sarcoma (STS) of the extremities to examine safety and feasibility of collaborating as a multi-institutional group for future research studies. From 2001 to 2009, twenty patients (median age 63.5 years) underwent TM-HILP for locally advanced in-transit melanoma (n=14) or unresectable STS (n=6). All patients underwent a 90-min isolated limb perfusion with melphalan (10 mg/l limb volume) and TNF-α (1-2 mg) under mild hyperthermia (39-40°C). No major intra-operative complications occurred and all patients completed the procedure successfully. One patient developed postoperative ischemic necrosis of the limb necessitating amputation. All melanoma patients showed a response to TM-HILP with 7 (62%) of them experiencing complete response. All STS patients attained complete response after excision of residual tumor. The median disease specific and limb-relapse-free survival was 15 and 12 months, respectively. TM-HILP can be safely applied even in low volume tertiary hospitals provided that technology to minimize intraoperative systemic leakage is available. Future prospective studies can be performed reproducibly by this multi-institutional collaborative group.
Journal Cover

April 2010
Volume 23 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

2012 Impact Factor: 2.297
Ranked #36/196 Oncology
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APA
Lasithiotakis, K., Economou, G., Gogas, H., Ioannou, C., Perisynakis, K., Filis, D., Kastana, O., Bafaloukos, D., Decatris, M., Catodritis, N., Frangia, K., Papadakis, G., Magarakis, M., Tsoutsos, D., Chrysos, E., Chalkiadakis, G., & Zoras, O. (2010). Hyperthermic isolated limb perfusion for recurrent melanomas and soft tissue sarcomas: Feasibility and reproducibility in a multi-institutional Hellenic collaborative study. Oncology Reports, 23(4), 1077-1083.
MLA
Lasithiotakis, Economou, Gogas, Ioannou, Perisynakis, Filis, Kastana, Bafaloukos, Decatris, Catodritis, Frangia, Papadakis, Magarakis, Tsoutsos, Chrysos, Chalkiadakis, and Odysseas Zoras. "Hyperthermic isolated limb perfusion for recurrent melanomas and soft tissue sarcomas: Feasibility and reproducibility in a multi-institutional Hellenic collaborative study." Oncology Reports Oncology Reports 23.4 (2010): 1077-1083.
Chicago
Lasithiotakis, Economou, Gogas, Ioannou, Perisynakis, Filis, Kastana, Bafaloukos, Decatris, Catodritis, Frangia, Papadakis, Magarakis, Tsoutsos, Chrysos, Chalkiadakis, and Odysseas Zoras. "Hyperthermic isolated limb perfusion for recurrent melanomas and soft tissue sarcomas: Feasibility and reproducibility in a multi-institutional Hellenic collaborative study." Oncology Reports Oncology Reports 23 no. 4 (2010): 1077-1083.