Open Access

Hyperthermic isolated limb perfusion for recurrent melanomas and soft tissue sarcomas: Feasibility and reproducibility in a multi-institutional Hellenic collaborative study

  • Authors:
    • Konstantinos Lasithiotakis
    • George Economou
    • Helen Gogas
    • Christos Ioannou
    • Konstantinos Perisynakis
    • Dimitrios Filis
    • Ourania Kastana
    • Dimitrios Bafaloukos
    • Marios Decatris
    • Nikolaos Catodritis
    • Konstantina Frangia
    • George Papadakis
    • Michael Magarakis
    • Dimosthenis Tsoutsos
    • Emmanuel Chrysos
    • George Chalkiadakis
    • Odysseas Zoras
  • Corresponding author:
  • View Affiliations

  • Published online on: Thursday, April 1, 2010
  • Pages: 1077-1083 DOI: 10.3892/or_00000735
  • Copyright: © Lasithiotakis et al. This is an open access article distributed under the terms of a Creative Commons Attribution License.

Abstract

Hyperthermic isolated limb perfusion with TNF-α and melphalan (TM-HILP) is a complicated surgical procedure. Herein, we present the experience of the Hellenic collaborating centers with TM-HILP for inoperable in-transit melanoma and soft tissue sarcoma (STS) of the extremities to examine safety and feasibility of collaborating as a multi-institutional group for future research studies. From 2001 to 2009, twenty patients (median age 63.5 years) underwent TM-HILP for locally advanced in-transit melanoma (n=14) or unresectable STS (n=6). All patients underwent a 90-min isolated limb perfusion with melphalan (10 mg/l limb volume) and TNF-α (1-2 mg) under mild hyperthermia (39-40°C). No major intra-operative complications occurred and all patients completed the procedure successfully. One patient developed postoperative ischemic necrosis of the limb necessitating amputation. All melanoma patients showed a response to TM-HILP with 7 (62%) of them experiencing complete response. All STS patients attained complete response after excision of residual tumor. The median disease specific and limb-relapse-free survival was 15 and 12 months, respectively. TM-HILP can be safely applied even in low volume tertiary hospitals provided that technology to minimize intraoperative systemic leakage is available. Future prospective studies can be performed reproducibly by this multi-institutional collaborative group.
Journal Cover

April 2010
Volume 23 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

2014 Impact Factor: 2.301
Ranked #31/211 Oncology
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Lasithiotakis, K., Economou, G., Gogas, H., Ioannou, C., Perisynakis, K., Filis, D. ... Zoras, O. (2010). Hyperthermic isolated limb perfusion for recurrent melanomas and soft tissue sarcomas: Feasibility and reproducibility in a multi-institutional Hellenic collaborative study. Oncology Reports, 23, 1077-1083. http://dx.doi.org/10.3892/or_00000735
MLA
Lasithiotakis, K., Economou, G., Gogas, H., Ioannou, C., Perisynakis, K., Filis, D., Kastana, O., Bafaloukos, D., Decatris, M., Catodritis, N., Frangia, K., Papadakis, G., Magarakis, M., Tsoutsos, D., Chrysos, E., Chalkiadakis, G., Zoras, O."Hyperthermic isolated limb perfusion for recurrent melanomas and soft tissue sarcomas: Feasibility and reproducibility in a multi-institutional Hellenic collaborative study". Oncology Reports 23.4 (2010): 1077-1083.
Chicago
Lasithiotakis, K., Economou, G., Gogas, H., Ioannou, C., Perisynakis, K., Filis, D., Kastana, O., Bafaloukos, D., Decatris, M., Catodritis, N., Frangia, K., Papadakis, G., Magarakis, M., Tsoutsos, D., Chrysos, E., Chalkiadakis, G., Zoras, O."Hyperthermic isolated limb perfusion for recurrent melanomas and soft tissue sarcomas: Feasibility and reproducibility in a multi-institutional Hellenic collaborative study". Oncology Reports 23, no. 4 (2010): 1077-1083. http://dx.doi.org/10.3892/or_00000735