Pre- and post-therapy nodal status equally affects survival of patients with oesophageal squamous cell carcinoma receiving preoperative chemoradiation

  • Authors:
    • Hiroshi Miyata
    • Makoto Yamasaki
    • Shuji Takiguchi
    • Kiyokazu Nakajima
    • Yoshiyuki Fujiwara
    • Masaki Mori
    • Yuichiro Doki
  • View Affiliations

  • Published online on: May 1, 2010     https://doi.org/10.3892/or_00000768
  • Pages: 1331-1337
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Abstract

Patients with deeply invading (T3-T4) oesophageal cancers usually receive chemoradiotherapy with or without surgery. However, the prognostic significance of pre-therapy and post-therapy lymph node (LN) status remains unclear. We studied 195 patients who received chemoradiotherapy for deeply invading oesophageal cancers (T3-4, N0-1, M0). Of these, 105 patients underwent surgery while 90 were treated by chemoradiotherapy alone. Of the 105 surgically treated patients, overall survival was significantly better in cN0 patients than in cN1 (3-year survival rate, 65.3 vs. 25.8%, P=0.0014). This difference was similarly observed in 90 patients who received chemoradiotherapy alone. Patient survival differed significantly among patients with no positive LN, 1 positive LN and 2-4 positive LN (3-year survival rate, 57.1 vs. 40.5 vs. 17.6%, P<0.0001). However, there was no significant difference in survival between patients with 2-4 positive LN and ≥5 positive LN. Multivariate analysis identified pre-therapy LN status and the number of involved LNs as the most important independent prognostic factors prior to histopathological tumour regression. In conclusion, pre-therapy LN status and the number of post-therapy involved LNs equally affect survival of patients who receive neo-adjuvant chemoradiotherapy. Control of systemic metastasis is required, based on pre- and post-therapy LN status.

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May 2010
Volume 23 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Miyata H, Yamasaki M, Takiguchi S, Nakajima K, Fujiwara Y, Mori M and Doki Y: Pre- and post-therapy nodal status equally affects survival of patients with oesophageal squamous cell carcinoma receiving preoperative chemoradiation . Oncol Rep 23: 1331-1337, 2010
APA
Miyata, H., Yamasaki, M., Takiguchi, S., Nakajima, K., Fujiwara, Y., Mori, M., & Doki, Y. (2010). Pre- and post-therapy nodal status equally affects survival of patients with oesophageal squamous cell carcinoma receiving preoperative chemoradiation . Oncology Reports, 23, 1331-1337. https://doi.org/10.3892/or_00000768
MLA
Miyata, H., Yamasaki, M., Takiguchi, S., Nakajima, K., Fujiwara, Y., Mori, M., Doki, Y."Pre- and post-therapy nodal status equally affects survival of patients with oesophageal squamous cell carcinoma receiving preoperative chemoradiation ". Oncology Reports 23.5 (2010): 1331-1337.
Chicago
Miyata, H., Yamasaki, M., Takiguchi, S., Nakajima, K., Fujiwara, Y., Mori, M., Doki, Y."Pre- and post-therapy nodal status equally affects survival of patients with oesophageal squamous cell carcinoma receiving preoperative chemoradiation ". Oncology Reports 23, no. 5 (2010): 1331-1337. https://doi.org/10.3892/or_00000768