IL-6 augments the invasiveness of U87MG human glioblastoma multiforme cells via up-regulation of MMP-2 and fascin-1

  • Authors:
    • Ronghui Li
    • Gang Li
    • Lin Deng
    • Qinglin Liu
    • Jun Dai
    • Jie Shen
    • Jian Zhang
  • Corresponding author:
  • View Affiliations

  • Published online on: Tuesday, June 1, 2010
  • Pages: 1553-1559 DOI: 10.3892/or_00000795

Abstract

Invasion into adjacent brain parenchyma is the key cause of recurrent human glioblastoma multiforme (GBM). The role of interleukin 6 (IL-6) in the malignant progression of glioma remains undefined. Here, we found that IL-6 promotes the invasion of U87 MG human glioma cells but not in U343 cells. An advanced level of STAT3 activity, and increased expression and secretion of MMP-2, induced by IL-6 in U87 MG cells were observed. Blocking the STAT3 pathway with specific inhibitors of STAT3, JSI-124 or small interfering RNA (siRNA), inhibited the invasion of U87MG promoted by IL-6 with concomitant down-regulation of MMP-2. Furthermore, rapid up-regulation of fascin-1 (a cell motility-related protein) induced by IL-6 was apparent in U87MG cells. However, this up-regulation of fascin-1 was not inhibited by JSI-124 or siRNA. These results suggest that the STAT3 pathway and fascin-1 may play crucial roles in the invasiveness of U87MG cells promoted by IL-6.
Journal Cover

June 2010
Volume 23 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

2013 Impact Factor: 2.191
2014 I.F. (Expected) ≥ 2.527 Ranked #33/202 Oncology
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APA
Li, R., Li, G., Deng, L., Liu, Q., Dai, J., Shen, J., & Zhang, J. (2010). IL-6 augments the invasiveness of U87MG human glioblastoma multiforme cells via up-regulation of MMP-2 and fascin-1 . Oncology Reports, 23, 1553-1559. http://dx.doi.org/10.3892/or_00000795
MLA
Li, R., Li, G., Deng, L., Liu, Q., Dai, J., Shen, J., Zhang, J."IL-6 augments the invasiveness of U87MG human glioblastoma multiforme cells via up-regulation of MMP-2 and fascin-1 ". Oncology Reports 23.6 (2010): 1553-1559.
Chicago
Li, R., Li, G., Deng, L., Liu, Q., Dai, J., Shen, J., Zhang, J."IL-6 augments the invasiveness of U87MG human glioblastoma multiforme cells via up-regulation of MMP-2 and fascin-1 ". Oncology Reports 23, no. 6 (2010): 1553-1559. http://dx.doi.org/10.3892/or_00000795